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Lofepramine

Name: Lofepramine
Brand: TargetMol
SKU: T15773
Rating: 4.5 (1 reviews)

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Catalog No. T15773Cas No. 23047-25-8

Alias Lopramine, Leo 640, Gamanil, Amplit

Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.

Lofepramine

😃Good

Catalog No. T15773Alias Lopramine, Leo 640, Gamanil, AmplitCas No. 23047-25-8

Pack Size	Price	Availability
2 mg	$41	Backorder
5 mg	$66	Backorder
10 mg	$91	Backorder
25 mg	$188	Backorder
50 mg	$281	Backorder
100 mg	$422	Backorder
1 mL x 10 mM (in DMSO)	$72	In Stock

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Product Introduction

Bioactivity

Description	Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
Targets&IC50	NET:5.4 nM(Kd), 5-HT:70 nM(Kd)
Synonyms	Lopramine, Leo 640, Gamanil, Amplit

Chemical Properties

Molecular Weight	418.96
Formula	C₂₆H₂₇ClN₂O
Cas No.	23047-25-8
Smiles	C(CCN(CC(=O)C1=CC=C(Cl)C=C1)C)N2C=3C(CCC=4C2=CC=CC4)=CC=CC3
Relative Density.	1.173g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 48 mg/mL (114.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3869 mL	11.9343 mL	23.8686 mL	119.3431 mL
5 mM	0.4774 mL	2.3869 mL	4.7737 mL	23.8686 mL
10 mM	0.2387 mL	1.1934 mL	2.3869 mL	11.9343 mL
20 mM	0.1193 mL	0.5967 mL	1.1934 mL	5.9672 mL
50 mM	0.0477 mL	0.2387 mL	0.4774 mL	2.3869 mL
100 mM	0.0239 mL	0.1193 mL	0.2387 mL	1.1934 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc