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Atomoxetine hydrochloride

Name: Atomoxetine hydrochloride
Brand: TargetMol
SKU: T0869
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0869Cas No. 82248-59-7

Alias Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochloride

Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

Atomoxetine hydrochloride

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Purity: 99.86%

Catalog No. T0869Alias Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochlorideCas No. 82248-59-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$36	In Stock	In Stock
50 mg	$48	In Stock	In Stock
100 mg	$68	In Stock	In Stock
500 mg	$173	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.
Targets&IC50	Dopamine transporter:1451 nM(Ki), 5-HT:77 nM(Ki), NET:5 nM(Ki)
In vitro	Atomoxetine selectively inhibited the presynaptic uptake of norepinephrine by adrenergic neurons in animals and was also active in an animal model of depression. In microdialysis studies, Atomoxetine had no effect on 5-HTEX levels but increased extracellular norepinephrine levels in the prefrontal cortex by 3-fold. Atomoxetine did not alter DAEX and Fos in the nucleus ambiguus and striatum, but increased DAEX concentrations in the PFC by 3-fold and Fos by 3.7-fold.
In vivo	Atomoxetine is a selective inhibitor of norepinephrine reuptake (Ki: 5 nM) and relatively unselective for 5-hydroxytryptamine (Ki: 77 nM) and dopamine transporter protein (Ki: 1451 nM).
Synonyms	Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochloride

Chemical Properties

Molecular Weight	291.82
Formula	C₁₇H₂₂ClNO
Cas No.	82248-59-7
Smiles	Cl.CNCC[C@@H](Oc1ccccc1C)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (856.69 mM), Sonication is recommended.

H2O: 6.9 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4268 mL	17.1338 mL	34.2677 mL	171.3385 mL
5 mM	0.6854 mL	3.4268 mL	6.8535 mL	34.2677 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.3427 mL	1.7134 mL	3.4268 mL	17.1338 mL
20 mM	0.1713 mL	0.8567 mL	1.7134 mL	8.5669 mL
50 mM	0.0685 mL	0.3427 mL	0.6854 mL	3.4268 mL
100 mM	0.0343 mL	0.1713 mL	0.3427 mL	1.7134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc