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ALLO-2

Name: ALLO-2
Brand: TargetMol
SKU: T14188
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14188Cas No. 1357350-60-7

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

ALLO-2

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Purity: 99.19%

Catalog No. T14188Cas No. 1357350-60-7

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$143	In Stock
10 mg	$223	In Stock
25 mg	$371	In Stock
50 mg	$527	In Stock
100 mg	$693	In Stock
200 mg	$953	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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Batch Information

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Purity:99.19%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Chemical Properties

Molecular Weight	371.32
Formula	C₁₈H₁₂F₃N₅O
Cas No.	1357350-60-7
Smiles	FC(F)(F)Oc1ccc(cc1)-c1ccnc(Nc2ccc3[nH]ncc3c2)n1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (336.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6931 mL	13.4655 mL	26.9309 mL	134.6547 mL
5 mM	0.5386 mL	2.6931 mL	5.3862 mL	26.9309 mL
10 mM	0.2693 mL	1.3465 mL	2.6931 mL	13.4655 mL
20 mM	0.1347 mL	0.6733 mL	1.3465 mL	6.7327 mL
50 mM	0.0539 mL	0.2693 mL	0.5386 mL	2.6931 mL
100 mM	0.0269 mL	0.1347 mL	0.2693 mL	1.3465 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc