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Varespladib

Name: Varespladib
Brand: TargetMol
SKU: T2044
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2044Cas No. 172732-68-2

Alias LY315920

Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusive crisis, and acute coronary syndrome.

Varespladib

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Purity: 99.97%

Catalog No. T2044Alias LY315920Cas No. 172732-68-2

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$147	In Stock
25 mg	$239	In Stock
50 mg	$355	In Stock
100 mg	$513	In Stock
200 mg	$743	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Purity:99.97%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the treatment and prevention of sickle cell disease, vaso-occlusive crisis, and acute coronary syndrome.
Targets&IC50	hnsPLA2:7 nM
In vitro	In transgenic mice expressing human sPLA2, oral or intravenous administration of LY315920 (0.3-3 mg/kg) effectively inhibits serum sPLA2 activity in a dose-dependent manner.
In vivo	In the absence of human sPLA2 in BAL cells, LY315920 (0.1 μM-3 μM) effectively suppresses thrombus formation regulated by human sPLA2 in a concentration-dependent manner. Additionally, in a human conjunctival epithelial cell line, LY315920 (10 μM) significantly inhibits the expression of membrane-bound mucin MUC16 induced by all-trans-retinoic acid (RA). LY315920 also markedly inhibits sPLA2 activity across various animal serums, demonstrated by its IC50 values: 8.1 nM in rats, 5.0 nM in rabbits, 3.2 nM in guinea pigs, and 6.2 nM in humans.
Synonyms	LY315920

Chemical Properties

Molecular Weight	380.39
Formula	C₂₁H₂₀N₂O₅
Cas No.	172732-68-2
Smiles	CCc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cccc2n1Cc1ccccc1
Relative Density.	1.32 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (157.73 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6289 mL	13.1444 mL	26.2888 mL	131.4440 mL
5 mM	0.5258 mL	2.6289 mL	5.2578 mL	26.2888 mL
10 mM	0.2629 mL	1.3144 mL	2.6289 mL	13.1444 mL
20 mM	0.1314 mL	0.6572 mL	1.3144 mL	6.5722 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6289 mL
100 mM	0.0263 mL	0.1314 mL	0.2629 mL	1.3144 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc