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Lapachol

Name: Lapachol
Brand: TargetMol
SKU: T4136
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4136Cas No. 84-79-7

Alias Tecomin, Greenhartin, CI75490, Bethabarra wood

Lapachol (CI75490) has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is an inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.

Lapachol

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Purity: 99.38%

Catalog No. T4136Alias Tecomin, Greenhartin, CI75490, Bethabarra woodCas No. 84-79-7

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$41	In Stock	In Stock
50 mg	$82	-	In Stock
100 mg	$124	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.38%

Color:Yellow

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COA LCMS HNMR

Product Introduction

Lapachol AI Summary

Lapachol exhibits a broad range of bioactivities and pharmacological properties. It demonstrates significant antitrypanosomal activity, particularly against Trypanosoma cruzi Y strain, with an IC50 value of 410800.0 nM after 24 hours, achieving a 65.0% lysis at a dose of 0.21 mM in the blood of infected mice. Additionally, it shows varying degrees of cytotoxicity across multiple human cancer cell lines, including an effective dose (ED50) of 4.4 µg/ml in KB cells and an IC50 of 3180.0 nM in HL60 cells by MTT assay. Against DU145 cells, the compound has a potent IC50 value of 64.59 nM after 72 hours. Its anticancer potential extends to other cell lines such as PC3, A549, and MCF7, with EC50 values of 1970.0 nM, 4780.0 nM, and 10150.0 nM, respectively. Lapachol also shows notable antimicrobial properties, inhibiting Mycobacterium tuberculosis with a Minimum Bactericidal Concentration (MBC) of 645.66 µM. It exhibits cytotoxic effects on WHCO1 and other cancer cell lines, suggesting its broad-spectrum antitumor activities, with GI50 values in the low micromolar range (2300.0 nM to 36000.0 nM). The compound displays selective bioactivities against Leishmania parasites, with moderate selectivity index ratios and potent inhibition of parasite growth in macrophages. Pharmacologically, Lapachol inhibits the binding of Yeast Glyoxalase I (Ki of 37153.52 nM), human SET7 enzyme, and shows significant inhibition against Trypanosoma cruzi cruzain. It showcases selective antimalarial activity, a high selectivity index in cytotoxicity assays, and bioactivity in inhibiting the binding of influenza virus polymerase subunit. The metabolic and physicochemical properties of Lapachol include a partition coefficient (log P) of 4.1, moderate metabolic stability, and inhibitory effects on specific transporters such as OATP1B1 and OATP1B3. Furthermore, it exhibits bioactivity related to various targets including JMJD2E, SMN2, tau fibrils, and Aldehyde Dehydrogenase 1. Overall, Lapachol holds promise for its diverse bioactivities including antimicrobial, antitrypanosomal, anticancer, and enzyme inhibitory effects, making it a potential candidate for further pharmacological development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lapachol (CI75490) has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is an inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.
Synonyms	Tecomin, Greenhartin, CI75490, Bethabarra wood

Chemical Properties

Molecular Weight	242.27
Formula	C₁₅H₁₄O₃
Cas No.	84-79-7
Smiles	CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O
Relative Density.	1.235 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (206.38 mM), Sonication is recommended.

Ethanol: 10 mg/mL (41.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1276 mL	20.6381 mL	41.2763 mL	206.3813 mL
5 mM	0.8255 mL	4.1276 mL	8.2553 mL	41.2763 mL
10 mM	0.4128 mL	2.0638 mL	4.1276 mL	20.6381 mL
20 mM	0.2064 mL	1.0319 mL	2.0638 mL	10.3191 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0826 mL	0.4128 mL	0.8255 mL	4.1276 mL
100 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0638 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc