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IMC-2C5 (Synonyms: IMC2C5, Anti-PDGFRB/CD140b Antibody)
Catalog No. T9901A-227 Copy Product Info
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IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b.
IMC-2C5
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Catalog No. T9901A-227
Synonyms IMC2C5, Anti-PDGFRB/CD140b Antibody
IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b.
IMC-2C5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $447 | - | In Stock | |
| 5 mg | $1,400 | - | In Stock | |
| 10 mg | $2,240 | - | In Stock | |
| 25 mg | $4,210 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Chemical Properties
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| Description | IMC-2C5 is a humanized monoclonal antibody targeting PDGFRB/CD140b. |
| Targets&IC50 | PDGFRβ (human):0.55 nM, PDGFRβ (Ms):0.35 nM |
| In vitro | The binding affinity of IMC-2C5 to hPDGFRβ and mPDGFRβ was 0.014 and 0.061 nM, respectively. IMC-2C5 inhibited the binding of hPDGFRβ to its ligand PDGF-B with an IC50 of 0.55 nM, while blocking the binding of mPDGFRβ to PDGF-B showed an IC50 of 0.35 nM. IMC-2C5 significantly inhibited the cell migration of PDGF-B (30 ng/ml) -stimulated NCI-H460, OVCAR-8, WS-1, and U-118MG cells expressing PDGFRβ. [1] |
| In vivo | IMC-2C5 showed significant antitumor activity in both OVCAR-8 and NCI-H460 xenograft models: At the end of treatment, it almost completely blocked the growth of OVCAR-8 tumors with a T/C of 39% and significantly slowed the growth of NCI-H460 tumors with a T/C of 60%. [1] |
| Synonyms | IMC2C5, Anti-PDGFRB/CD140b Antibody |
| Clone | IMC-2C5 |
| Reactivity | Human |
| Verified Activity | Immobilized Human PDGFB/CD140b Protein (His) at 2 μg/mL can bind IMC-2C5. The EC50 is 0.003937 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDGFRB/CD140b |
| Molecular Weight | 145.06 kDa |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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