EGFR Protein, Human, Recombinant (CHO, His)

Name: EGFR Protein, Human, Recombinant (CHO, His)
Brand: TargetMol
SKU: TMPS-00022
Rating: 4.5 (1 reviews)

(Synonyms: HER1, ERBB1, ERBB) Copy Product Info

Synonyms: HER1, ERBB1, ERBB

Catalog No. TMPS-00022 Copy Product Info

EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$98	7-10 days	7-10 days
10 µg	$170	7-10 days	7-10 days
20 µg	$248	7-10 days	7-10 days
50 µg	$423	7-10 days	7-10 days
100 µg	$682	7-10 days	7-10 days
200 µg	$1,080	7-10 days	7-10 days
500 µg	$1,980	7-10 days	7-10 days
1 mg	$3,390	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 1.0 μg/ml, measured in a bioassay using 3T3 cells in the presence of 25.0 pg/ml human EGF.
Description	EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.
Species	Human
Expression System	CHO Cells
Tag	His
Accession Number	P00533-1
Construction	Leu25-Ser645
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	HER1, ERBB1, ERBB
Research Background	EGF Receptor, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. It belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2, 3, and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF, Heparin-Binding EGF and Transforming Growth Factor α. Upon ligand binding, EGFR undergoes asymmetric dimerization, composed of an “activator” and a “receiver”. EGFR and its family members are disregulated in numerous cancers. In particular, EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis.

Chemical Properties

Molecular Weight

95~115 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.