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EGFR Protein, Human, Recombinant (CHO, His)

Catalog No. TMPS-00022

EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.

EGFR Protein, Human, Recombinant (CHO, His)

EGFR Protein, Human, Recombinant (CHO, His)

Catalog No. TMPS-00022
EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.
Pack SizePriceAvailabilityQuantity
10 μg $1707-10 days
50 μg $4237-10 days
1 mg $3,3907-10 days
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Product Information

Biological Activity
ED 50 < 1.0 μg/ml, measured in a bioassay using 3T3 cells in the presence of 25.0 pg/ml human EGF.
Description
EGFR Protein, Human, Recombinant (CHO, His) is expressed in CHO Cells. The accession number is P00533-1.
Species
Human
Expression System
CHO Cells
TagHis
Accession NumberP00533-1
Synonyms
HER1,ERBB1,ERBB
Construction
Leu25-Ser645
Protein Purity
> 95% as determined by SDS-PAGE
Molecular Weight95~115 kDa (Reducing conditions)
Endotoxin< 0.2 EU/μg of protein as determined by the LAL method.
FormulationLyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution
Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
EGF Receptor, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. It belongs to a family of tyrosine kinase receptors including Human EGF Receptors (HER) 2, 3, and 4 which all play important roles in cell growth and differentiation. Their primary ligands are EGF, Heparin-Binding EGF and Transforming Growth Factor α. Upon ligand binding, EGFR undergoes asymmetric dimerization, composed of an “activator” and a “receiver”. EGFR and its family members are disregulated in numerous cancers. In particular, EGFR is overexpressed in many epithelial solid tumors. Evidence suggests EGFR is an excellent target for pharmacologic intervention in Non Small Cell Lung Cancer (NSCLC) due to its high level of expression and prominent role in tumor growth and metastasis.

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.