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SNC 80

Catalog No. T8414 CAS 156727-74-1

Synonyms: Snc-80, SNC80, NIH 10815

SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SNC 80, CAS 156727-74-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 35.00
5 mg	In stock	$ 74.00
10 mg	In stock	$ 123.00
25 mg	In stock	$ 297.00
50 mg	In stock	$ 416.00

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Purity: 98.67%

Biological Description

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Storage & Solubility Information

Description	SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.
In vitro	SNC80 selectively targets and activates the μ-δ heteromer within HEK293 cells, displaying an EC50 value of 52.8 nM. It demonstrates significantly higher activity in cells coexpressing μ- and δ-opioid receptors compared to those solely expressing δ-opioid receptors or those coexpressing δ- and κ-opioid receptors [4].
In vivo	SNC80 (10 mg/kg; intraperitoneal injection; once) treatment significantly attenuated this allodynia caused by overuse of Sumatriptan in C57BL6/J mice [1].

Synonyms	Snc-80, SNC80, NIH 10815
Molecular Weight	449.63
Formula	C28H39N3O2
CAS No.	156727-74-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL (2.22 mM), Sonication is recommended.

References and Literature

1. Moye LS, et al. Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology. 2019 Apr;148:77-86. 2. Bilsky EJ, et al. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. J Pharmacol Exp Ther. 1995 Apr;273(1):359-66. 3. zinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. J Med Chem. 1994 Jul 8;37(14):2125-8. 4. Metcalf MD, et al. The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9. 5. Vicente-Sanchez A, et al. The delta opioid receptor tool box. Neuroscience. 2016 Dec 3;338:145-159. 6. ripps IJ, et al. Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80. Br J Pharmacol. 2018 Mar;175(6):891-901.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library ReFRAME Related Library Bioactive Compound Library Antidepressant Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SNC 80 156727-74-1 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Snc-80 SNC-80 NIH-10815 SNC80 NIH 10815 NIH10815 inhibitor inhibit

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