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Anti-GFR Alpha-2/GFRA2 Antibody (5Q415)
😃Good
Catalog No. TMAY-00619
Alias Trnr2, GFR α-2/GFRA2, Gdnfrb, GDNF family receptor α2, GDNF family receptor alpha 2
Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) is a Rabbit antibody targeting GFR Alpha-2/GFRA2. Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) can be used in ELISA.
Anti-GFR Alpha-2/GFRA2 Antibody (5Q415)
Anti-GFR Alpha-2/GFRA2 Antibody (5Q415)
😃Good
Catalog No. TMAY-00619Alias Trnr2, GFR α-2/GFRA2, Gdnfrb, GDNF family receptor α2, GDNF family receptor alpha 2
Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) is a Rabbit antibody targeting GFR Alpha-2/GFRA2. Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Chemical Properties
| Description | Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) is a Rabbit antibody targeting GFR Alpha-2/GFRA2. Anti-GFR Alpha-2/GFRA2 Antibody (5Q415) can be used in ELISA. |
| Alias | Trnr2, GFR α-2/GFRA2, Gdnfrb, GDNF family receptor α2, GDNF family receptor alpha 2 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5Q415 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA2 (rh GFRA2; TMPY-01420; NP_001486.4; Met 1-Ser 441). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA/GDNFRa acts as the ligand-binding component. Experiments have improved that GFRA2 genetic variants and age may play a role in Tardive dyskinesia (TD) susceptibility, but further work is required to confirm these findings. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human GFRA2 protein (TMPY-01420) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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