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Colchicoside

Name: Colchicoside
Brand: TargetMol
SKU: T36115
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36115Cas No. 477-29-2

Alias 3-Demethylcolchicine glucoside

Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma.

Colchicoside

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Purity: 99.76%

Catalog No. T36115Alias 3-Demethylcolchicine glucosideCas No. 477-29-2

Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	-	In Stock
5 mg	$52	-	In Stock
10 mg	$73	-	In Stock
25 mg	$145	-	In Stock
50 mg	$219	-	In Stock
100 mg	$326	-	In Stock
1 mL x 10 mM (in DMSO)	$79	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Colchicoside (3-Demethylcolchicine glucoside) is extracted from Gloriosa superba and shows efficacy in a murine model of pancreatic adenocarcinoma.
In vitro	Colchicoside (1 and 10 μM) increases levels of CYP2C9 and CYP2E1 in primary human hepatocytes[3].
Synonyms	3-Demethylcolchicine glucoside

Chemical Properties

Molecular Weight	547.55
Formula	C₂₇H₃₃NO₁₁
Cas No.	477-29-2
Smiles	COC1=C(OC)C2=C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)C=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 27 mg/mL (49.31 mM), Sonication is recommended.

DMSO: 150 mg/mL (273.95 mM), Sonication is recommended.

PBS (pH 7.2): 10 mg/mL (18.26 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8263 mL	9.1316 mL	18.2632 mL	91.3159 mL
5 mM	0.3653 mL	1.8263 mL	3.6526 mL	18.2632 mL
10 mM	0.1826 mL	0.9132 mL	1.8263 mL	9.1316 mL

DMF/DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0913 mL	0.4566 mL	0.9132 mL	4.5658 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0365 mL	0.1826 mL	0.3653 mL	1.8263 mL
100 mM	0.0183 mL	0.0913 mL	0.1826 mL	0.9132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc