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RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology.

| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $73 | In Stock |
| Description | RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology. |
| Targets&IC50 | Hhat:850 nM |
| In vitro | Method: AsPC-1 cells were treated with RU-SKI 43 Hydrochloride (10 μM, 72 hours), and Gli-1 mRNA levels were detected by qRT-PCR. Result: RU-SKI 43 Hydrochloride reduced Gli-1 levels in AsPC-1 cells by 40%. [2] |
| In vivo | After IV administration,RU-SKI 43 Hydrochloride has a t1/2 of 17 min in mouse plasma.[1] |
| Synonyms | RU-SKI43 Hydrochloride |
| Molecular Weight | 423.01 |
| Formula | C22H31ClN2O2S |
| Cas No. | 1782573-67-4 |
| Smiles | Cl.O=C(N1CCC=2SC=CC2C1COC3=CC=CC(=C3)C)CNCC(C)CC |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: ≥ 40 mg/mL, Sonication is recommended. H2O: 2 mg/mL (4.73 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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