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RU-SKI 43 Hydrochloride

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Catalog No. T12797LCas No. 1782573-67-4
Alias RU-SKI43 Hydrochloride

RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology.

RU-SKI 43 Hydrochloride
Other Forms of RU-SKI 43 Hydrochloride:
RU-SKI 43T127971043797-53-0
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RU-SKI 43 Hydrochloride

🥰Excellent
Catalog No. T12797LAlias RU-SKI43 HydrochlorideCas No. 1782573-67-4
RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology.
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2 mg$73In Stock
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Product Introduction

Bioactivity
Description
RU-SKI 43 Hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat), with an IC50 value of 850 nM. RU-SKI 43 Hydrochloride has been reported to possess anticancer activity, making it a useful compound for investigating Hedgehog signaling in tumor biology.
Targets&IC50
Hhat:850 nM
In vitro
Method: AsPC-1 cells were treated with RU-SKI 43 Hydrochloride (10 μM, 72 hours), and Gli-1 mRNA levels were detected by qRT-PCR.
Result: RU-SKI 43 Hydrochloride reduced Gli-1 levels in AsPC-1 cells by 40%. [2]
In vivo
After IV administration,RU-SKI 43 Hydrochloride has a t1/2 of 17 min in mouse plasma.[1]
SynonymsRU-SKI43 Hydrochloride
Chemical Properties
Molecular Weight423.01
FormulaC22H31ClN2O2S
Cas No.1782573-67-4
SmilesCl.O=C(N1CCC=2SC=CC2C1COC3=CC=CC(=C3)C)CNCC(C)CC
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: ≥ 40 mg/mL, Sonication is recommended.
H2O: 2 mg/mL (4.73 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.3640 mL11.8201 mL23.6401 mL118.2005 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

RU-SKI 43 HydrochlorideRUSKI 43 hydrochlorideRU SKI 43 hydrochlorideHhat
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