Detomidine carboxylic acid

Name: Detomidine carboxylic acid
Brand: TargetMol
SKU: T11010
Rating: 4.5 (1 reviews)

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Catalog No. T11010Cas No. 115664-39-6

Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect.

Detomidine carboxylic acid

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Catalog No. T11010Cas No. 115664-39-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,720	3-6 months	3-6 months
50 mg	$3,580	3-6 months	3-6 months
100 mg	$4,900	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description

In vivo

After oral administration of Detomidine, an analgesic sedative for large animals, to two stallions and intravenous injection of [3H]-Detomidine into mares, the metabolites in horse urine were studied. After oral doses, a combination of totomidine carboxylic acid and hydroxytomtomidine glucuronic acid was identified in the urine. About 12 hours after the intravenous injection, about half of the radioactivity of [3H]-tomtomidine was excreted into the urine. Dose (80μg/kg). Compared with the highest urine output 2 to 5 hours after urination, most excretion occurs between 5 and 12 hours. The main radioactive metabolite in urine is totomidine carboxylic acid. In all collected urine fractions, totomidine carboxylic acid accounts for more than two-thirds of the total metabolites.

Chemical Properties

Molecular Weight	216.24
Formula	C₁₂H₁₂N₂O₂
Cas No.	115664-39-6
Smiles	O=C(O)C1=CC=CC(=C1C)CC2=CN=CN2
Relative Density.	1.278g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc