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Anti-Frizzled-8 Antibody (5A651)
😃Good
Catalog No. TMAC-01564
Alias hFZ8, FZD8, FZ-8, Frizzled-8, Frizzled8, frizzled family receptor 8, frizzled 8
Anti-Frizzled-8 Antibody (5A651) is a Rabbit antibody targeting Frizzled-8. Anti-Frizzled-8 Antibody (5A651) can be used in WB,IHC.
Anti-Frizzled-8 Antibody (5A651)
Anti-Frizzled-8 Antibody (5A651)
😃Good
Catalog No. TMAC-01564Alias hFZ8, FZD8, FZ-8, Frizzled-8, Frizzled8, frizzled family receptor 8, frizzled 8
Anti-Frizzled-8 Antibody (5A651) is a Rabbit antibody targeting Frizzled-8. Anti-Frizzled-8 Antibody (5A651) can be used in WB,IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Frizzled-8 Antibody (5A651) is a Rabbit antibody targeting Frizzled-8. Anti-Frizzled-8 Antibody (5A651) can be used in WB,IHC. |
| Alias | hFZ8, FZD8, FZ-8, Frizzled-8, Frizzled8, frizzled family receptor 8, frizzled 8 |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Verified Activity | 1. Western blot analysis of Frizzled 8 on mouse lung tissue lysates using anti-Frizzled 8 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Frizzled 8 antibody. Counter stained with hematoxylin. |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 73 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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