Anti-CYP1A1 Polyclonal Antibody

Name: Anti-CYP1A1 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00522
Rating: 4.5 (1 reviews)

(Synonyms: Hydroperoxy icosatetraenoate dehydratase, Cytochrome P450-P1, Cytochrome P450-C, Cytochrome P450 form 6, Cytochrome P450 1A1, CYPIA1, CYP1A1) Copy Product Info

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Synonyms: Hydroperoxy icosatetraenoate dehydratase, Cytochrome P450-P1, Cytochrome P450-C, Cytochrome P450 form 6, Cytochrome P450 1A1, CYPIA1, CYP1A1

Catalog No. TMAB-00522 Copy Product Info

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Anti-CYP1A1 Polyclonal Antibody is a Rabbit antibody targeting CYP1A1. Anti-CYP1A1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

Anti-CYP1A1 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$221	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$527	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Description	Anti-CYP1A1 Polyclonal Antibody is a Rabbit antibody targeting CYP1A1. Anti-CYP1A1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	Hydroperoxy icosatetraenoate dehydratase, Cytochrome P450-P1, Cytochrome P450-C, Cytochrome P450 form 6, Cytochrome P450 1A1, CYPIA1, CYP1A1
Ig Type	IgG
Reactivity	Human,Mouse,Rat (predicted:Pig)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Endoplasmic reticulum
Tissue Specificity	Lung, lymphocytes and placenta.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human CYP1A1
Antigen Species	Human
Gene Name	CYP1A1
Gene ID	1543
Protein Name	Cytochrome P450 1A1
Uniprot ID	P04798
Biology Area	Drug metabolism,Cancer,Cytochromes,Hypoxia,Lipases,Drug metabolism,Cytochromes,Response to hypoxia,Cellular metabolic process
Function	Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.