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Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody
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Catalog No. TMAB-10538
Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CREB-1 (Ser129). Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody can be used in WB.
Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody
Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody
😃Good
Catalog No. TMAB-10538
Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CREB-1 (Ser129). Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CREB-1 (Ser129). Anti-Phospho-CREB-1 (Ser129) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Pig,Horse,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF-2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265kDa nuclear protein designated CBP (CREB-binding protein), which may reprecent a CREB co-activator. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human CREB-1 around the phosphorylation site of Ser129 |
| Antigen Species | Human |
| Gene Name | CREB1 |
| Gene ID | |
| Protein Name | Cyclic AMP-responsive element-binding protein 1 |
| Uniprot ID | |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. |
| Molecular Weight | Theoretical: 37 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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