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BAY 1892005

🥰Excellent
Catalog No. T77768Cas No. 2036352-13-1

BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

BAY 1892005

BAY 1892005

🥰Excellent
Purity: 99.42%
Catalog No. T77768Cas No. 2036352-13-1
BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$56-In Stock
5 mg$137-In Stock
10 mg$223-In Stock
25 mg$368-In Stock
50 mg$521-In Stock
100 mg$702-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.42%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
Targets&IC50
H358 cells:11.1 μM, p53-mutant:11.2 μM
In vitro
In p53-mutant cell lines Huh7 (IC50=11.2 μM) and H358 (IC50=11.1 μM), BAY 1892005 inhibits cell proliferation[1].
Chemical Properties
Molecular Weight270.71
FormulaC11H8ClFN2OS
Cas No.2036352-13-1
SmilesO=C(NC1=NC(=CS1)C=2C=CC=CC2F)CCl
Relative Density.1.454 g/cm3 at 20℃ (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 65 mg/mL (240.11 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6940 mL18.4699 mL36.9399 mL184.6995 mL
5 mM0.7388 mL3.6940 mL7.3880 mL36.9399 mL
10 mM0.3694 mL1.8470 mL3.6940 mL18.4699 mL
20 mM0.1847 mL0.9235 mL1.8470 mL9.2350 mL
50 mM0.0739 mL0.3694 mL0.7388 mL3.6940 mL
100 mM0.0369 mL0.1847 mL0.3694 mL1.8470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

p53BAY1892005
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