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BAY 1892005

Name: BAY 1892005
Brand: TargetMol
SKU: T77768
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77768Cas No. 2036352-13-1

BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

BAY 1892005

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Purity: 99.42%

Catalog No. T77768Cas No. 2036352-13-1

BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
5 mg	$137	-	In Stock
10 mg	$223	-	In Stock
25 mg	$368	-	In Stock
50 mg	$521	-	In Stock
100 mg	$702	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
Targets&IC50	p53-mutant:11.2 μM, H358 cells:11.1 μM
In vitro	In p53-mutant cell lines Huh7 (IC50=11.2 μM) and H358 (IC50=11.1 μM), BAY 1892005 inhibits cell proliferation[1].

Chemical Properties

Molecular Weight	270.71
Formula	C₁₁H₈ClFN₂OS
Cas No.	2036352-13-1
Smiles	O=C(NC1=NC(=CS1)C=2C=CC=CC2F)CCl
Relative Density.	1.454 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (240.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6940 mL	18.4699 mL	36.9399 mL	184.6995 mL
5 mM	0.7388 mL	3.6940 mL	7.3880 mL	36.9399 mL
10 mM	0.3694 mL	1.8470 mL	3.6940 mL	18.4699 mL
20 mM	0.1847 mL	0.9235 mL	1.8470 mL	9.2350 mL
50 mM	0.0739 mL	0.3694 mL	0.7388 mL	3.6940 mL
100 mM	0.0369 mL	0.1847 mL	0.3694 mL	1.8470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc