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BAY 1892005

Name: BAY 1892005
Brand: TargetMol
SKU: T77768
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77768Cas No. 2036352-13-1

BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

BAY 1892005

🥰Excellent

Purity: 99.62%

Catalog No. T77768Cas No. 2036352-13-1

BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$228	In Stock
10 mg	$372	In Stock
25 mg	$613	In Stock
50 mg	$869	In Stock
100 mg	$1,170	In Stock
500 mg	$2,330	In Stock

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Batch Information

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Purity:99.62%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein
Targets&IC50	H358 cells:11.1 μM, p53-mutant:11.2 μM
In vitro	In p53-mutant cell lines Huh7 (IC50=11.2 μM) and H358 (IC50=11.1 μM), BAY 1892005 inhibits cell proliferation[1].

Chemical Properties

Molecular Weight	270.71
Formula	C₁₁H₈ClFN₂OS
Cas No.	2036352-13-1
Smiles	O=C(NC1=NC(=CS1)C=2C=CC=CC2F)CCl
Relative Density.	1.454 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (240.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6940 mL	18.4699 mL	36.9399 mL	184.6995 mL
5 mM	0.7388 mL	3.6940 mL	7.3880 mL	36.9399 mL
10 mM	0.3694 mL	1.8470 mL	3.6940 mL	18.4699 mL
20 mM	0.1847 mL	0.9235 mL	1.8470 mL	9.2350 mL
50 mM	0.0739 mL	0.3694 mL	0.7388 mL	3.6940 mL
100 mM	0.0369 mL	0.1847 mL	0.3694 mL	1.8470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc