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4-Hydroxycoumarin

Name: 4-Hydroxycoumarin
Brand: TargetMol
SKU: PDK0015
Rating: 4.5 (1 reviews)

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Catalog No. PDK0015Cas No. 1076-38-6

4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.

4-Hydroxycoumarin

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Purity: 99.85%

Catalog No. PDK0015Cas No. 1076-38-6

4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

4-Hydroxycoumarin AI Summary

4-Hydroxycoumarin exhibits a broad spectrum of biological activities including notable inhibitory activity against various enzymes, antioxidant properties, cytotoxicity against human and mouse cell lines, and specific bioactivities relevant to pharmaceutical and agricultural applications. Specifically, it inhibits HIV-1 integrase with an IC50 value greater than 100,000 nM and xanthine oxidase with an IC50 value of 195,000 nM. It shows antioxidant activity by scavenging DPPH and ABTS radicals, inhibiting hydroxyl radical production, and demonstrating a trolox equivalent antioxidant capacity of 186.0 umolequiv/g in the ABTS assay. The compound also displays notable inhibition against several human carbonic anhydrases, particularly CA9 (Ki = 410.0 nM) and moderate activity against CA1 (Ki = 95,000.0 nM). 4-Hydroxycoumarin is cytotoxic to various human and mouse cell lines, including TK10, UACC62, MCF7, and B16F10, with IC50 values ranging from 600.0 nM to over 200,000.0 nM, indicating varying degrees of potency. It shows some selectivity in its anticancer activity against melanoma cell lines SK-MEL3 (IC50 = 2100.0 nM) and SK-MEL-28 (IC50 = 1300.0 nM). The compound also exhibits antifungal activity against Aspergillus fumigatus at lower concentrations and stimulatory activity on the growth of Colletotrichum acutatum. Additionally, 4-Hydroxycoumarin displays bioactivity in expressed human recombinant UGT enzymes, specifically showing activity in UGT1A7, UGT1A8, and UGT2A1. It provides gastric cytoprotection in male Wistar rats with a cytoprotective effect score of 4.62. The compound also inhibits alpha-glucosidase enzyme with an IC50 value of 400,000 uM and demonstrates binding affinity to CK2alpha as indicated by a delta melting temperature of 3.8 degrees Celsius. Overall, 4-Hydroxycoumarin shows potential for further development in various therapeutic and agricultural domains due to its diverse bioactivities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

4-Hydroxycoumarin is a coumarin derivative and one of the versatile heterocyclic scaffolds with electrophilic and nucleophilic properties.

Chemical Properties

Molecular Weight	162.14
Formula	C₉H₆O₃
Cas No.	1076-38-6
Smiles	OC1=CC(=O)OC2=CC=CC=C12
Relative Density.	1.1734 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Methanol: 20 mg/mL (123.35 mM), Sonication is recommended.

DMSO: 50 mg/mL (308.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1675 mL	30.8375 mL	61.6751 mL	308.3755 mL
5 mM	1.2335 mL	6.1675 mL	12.3350 mL	61.6751 mL
10 mM	0.6168 mL	3.0838 mL	6.1675 mL	30.8375 mL
20 mM	0.3084 mL	1.5419 mL	3.0838 mL	15.4188 mL
50 mM	0.1234 mL	0.6168 mL	1.2335 mL	6.1675 mL
100 mM	0.0617 mL	0.3084 mL	0.6168 mL	3.0838 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc