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Anti-Fetuin A Antibody (9Y147)
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Catalog No. TMAY-03100
Alias α-2-HS-glycoprotein, alpha-2-HS-glycoprotein
Anti-Fetuin A Antibody (9Y147) is a Rabbit antibody targeting Fetuin A. Anti-Fetuin A Antibody (9Y147) can be used in IHC-P.
Anti-Fetuin A Antibody (9Y147)
Anti-Fetuin A Antibody (9Y147)
😃Good
Catalog No. TMAY-03100Alias α-2-HS-glycoprotein, alpha-2-HS-glycoprotein
Anti-Fetuin A Antibody (9Y147) is a Rabbit antibody targeting Fetuin A. Anti-Fetuin A Antibody (9Y147) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Fetuin A Antibody (9Y147) is a Rabbit antibody targeting Fetuin A. Anti-Fetuin A Antibody (9Y147) can be used in IHC-P. |
| Alias | α-2-HS-glycoprotein, alpha-2-HS-glycoprotein |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 9Y147 |
| Reactivity | Mouse |
| Verified Activity | Immunochemical staining of mouse AHSG in mouse liver (from 2 donors) with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Fetuin-A / AHSG (rM Fetuin-A / AHSG; TMPY-00802; NP_038493.1; Met1-Ile345). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse Fetuin-A / AHSG protein (TMPY-00802) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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