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Tucatinib

Name: Tucatinib
Brand: TargetMol
SKU: T2364
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2364Cas No. 937263-43-9

Alias ONT-380, Irbinitinib, ARRY-380

Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

Tucatinib

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Purity: 99.96%

Catalog No. T2364Alias ONT-380, Irbinitinib, ARRY-380Cas No. 937263-43-9

Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$45	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$126	In Stock	In Stock
50 mg	$197	In Stock	In Stock
100 mg	$369	In Stock	In Stock
500 mg	$869	-	In Stock
1 g	$1,190	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Color:White

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Product Introduction

Bioactivity

Description	Tucatinib (ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).
Targets&IC50	ErbB2:8 nM
In vitro	Irbinitinib selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells.
In vivo	In vivo,Tucatinib significantly inhibits tumor growth in multiple HER2-dependent tumor xenograft models[2]. It shows excellent activity in numerous mouse tumor models including breast (BT-474, MDA-MB-453), ovarian (SKOV-3) and gastric (N87) carcinoma models. In the BT-474 model,Tucatinib demonstrated significant dose-related tumor growth inhibition (TGI; 50% at 50 mg/kg/d and 96% at 100 mg/kg/d) with numerous partial regressions (>50% reduction from baseline size)[1].
Synonyms	ONT-380, Irbinitinib, ARRY-380

Chemical Properties

Molecular Weight	480.52
Formula	C₂₆H₂₄N₈O₂
Cas No.	937263-43-9
Smiles	Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (93.65 mM), Sonication is recommended.

Ethanol: 15 mg/mL (31.22 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0811 mL	10.4054 mL	20.8108 mL	104.0539 mL
5 mM	0.4162 mL	2.0811 mL	4.1622 mL	20.8108 mL
10 mM	0.2081 mL	1.0405 mL	2.0811 mL	10.4054 mL
20 mM	0.1041 mL	0.5203 mL	1.0405 mL	5.2027 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0811 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc