Shopping Cart

Your shopping cart is currently empty

L524-0366

Name: L524-0366
Brand: TargetMol
SKU: T8570
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T8570Cas No. 951612-19-4

Alias [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone

L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.

L524-0366

😃Good

Purity: 99.13%

Catalog No. T8570Alias [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanoneCas No. 951612-19-4

L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	In Stock	In Stock
5 mg	$247	In Stock	In Stock
10 mg	$378	In Stock	In Stock
25 mg	$653	In Stock	In Stock
50 mg	$892	In Stock	In Stock
100 mg	$1,180	In Stock	In Stock
200 mg	$1,620	-	In Stock
1 mL x 10 mM (in DMSO)	$255	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.13%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	L524-0366 ([1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone) is a TWEAK-Fn14 signaling cascade inhibitor.
Targets&IC50	sTWEAK:7.8 µM
In vitro	L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
Cell Research	Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.
Synonyms	[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone

Chemical Properties

Molecular Weight	308.79
Formula	C₁₃H₁₃ClN₄OS
Cas No.	951612-19-4
Smiles	C(=O)(C1=CN(N=N1)C2=CC(Cl)=CC=C2)N3CCSCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (80.96 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO+95% Corn oil: 1 mg/mL (3.24 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2384 mL	16.1922 mL	32.3845 mL	161.9223 mL
5 mM	0.6477 mL	3.2384 mL	6.4769 mL	32.3845 mL
10 mM	0.3238 mL	1.6192 mL	3.2384 mL	16.1922 mL
20 mM	0.1619 mL	0.8096 mL	1.6192 mL	8.0961 mL
50 mM	0.0648 mL	0.3238 mL	0.6477 mL	3.2384 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc