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2,4-Diacetylphloroglucinol

Name: 2,4-Diacetylphloroglucinol
Brand: TargetMol
SKU: T21619
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21619Cas No. 2161-86-6

2,4-Diacetylphloroglucinol is a polyketide antibiotic discovered in Pseudomonas fluorescens, exhibiting broad-spectrum toxicity against bacteria, fungi, oomycetes, nematodes, and plant pathogens.

2,4-Diacetylphloroglucinol

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Purity: 99.71%

Catalog No. T21619Cas No. 2161-86-6

2,4-Diacetylphloroglucinol is a polyketide antibiotic discovered in Pseudomonas fluorescens, exhibiting broad-spectrum toxicity against bacteria, fungi, oomycetes, nematodes, and plant pathogens.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$48	-	In Stock
50 mg	$68	-	In Stock
100 mg	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.71%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	2,4-Diacetylphloroglucinol is a polyketide antibiotic discovered in Pseudomonas fluorescens, exhibiting broad-spectrum toxicity against bacteria, fungi, oomycetes, nematodes, and plant pathogens.
In vitro	2,4-Diacetylphloroglucinol (0–100 μM, 0–4 days) inhibited primary root elongation, promoted lateral root formation, and induced necrosis at the primary root tip along with purple stress phenotypes in the hypocotyl when applied to Solanum lycopersicum and Solanum melongena seedlings. Its mechanism of action is associated with the regulation of auxin signaling pathways [1]. 2,4-Diacetylphloroglucinol (0–40 μg/mL, 0–6 hours) was capable of suppressing the formation and motility of zoospores in Plasmopara viticola and Aphanomyces cochlioides [2].
In vivo	2,4-Diacetylphloroglucinol (0–100 μg/mL, incubation treatment for 0–7 days) exhibited toxic effects on adult Xiphinema americanum, with an LD50 of 8.3 μg/mL. It also inhibited the egg hatching rate of Meloidogyne incognita, but displayed a unique phenomenon of stimulating egg hatching during the early incubation period in Caenorhabditis elegans [3].

Chemical Properties

Molecular Weight	210.18
Formula	C₁₀H₁₀O₅
Cas No.	2161-86-6
Smiles	O=C(C1=C(O)C=C(O)C(=C1O)C(=O)C)C
Relative Density.	1.422g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (380.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7578 mL	23.7891 mL	47.5783 mL	237.8913 mL
5 mM	0.9516 mL	4.7578 mL	9.5157 mL	47.5783 mL
10 mM	0.4758 mL	2.3789 mL	4.7578 mL	23.7891 mL
20 mM	0.2379 mL	1.1895 mL	2.3789 mL	11.8946 mL
50 mM	0.0952 mL	0.4758 mL	0.9516 mL	4.7578 mL
100 mM	0.0476 mL	0.2379 mL	0.4758 mL	2.3789 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc