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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $63 | In Stock | |
10 mg | $96 | In Stock | |
25 mg | $158 | In Stock | |
50 mg | $238 | In Stock | |
100 mg | $353 | In Stock | |
500 mg | $839 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties. |
In vitro | METHODS: Human colorectal cancer cells HCT-116 were treated with Notoginsenoside R1 (75-300 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Cell viability of HCT-116 cells treated with 75-300 µM Notoginsenoside R1 was not significantly different from that of the control. However, treatment with 500 µM Notoginsenoside R1 for 48 h resulted in a significant decrease in cell viability (58±7.26%) compared to control cells. [1] METHODS: Human coronary artery smooth muscle cells hCASMC were treated with Notoginsenoside R1 (10 µM) for 24 h. The cells were stimulated with 10% FBS for 0-30 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Akt phosphorylation in hCASMCs was rapidly reduced in a time- and dose-dependent manner after Notoginsenoside R1 treatment, but no effect on ERK1/2 and JNK signaling was observed. notoginsenoside R1 caused a modest reduction in p38 MAPK phosphorylation, but this did not reach significance. [2] |
In vivo | METHODS: To study the effect on neoplastic endothelial hyperplasia, Notoginsenoside R1 (10 mg/kg) was administered intraperitoneally to C57BL/6 J mice once daily for three weeks. A mouse femoral artery injury model was subsequently performed. RESULTS: Notoginsenoside R1 attenuated neointimal formation after femoral artery injury in vivo.Notoginsenoside R1 treatment reduced neointimal formation by inhibiting VSMC proliferation. [2] |
Alias | Sanqi glucoside R1, Sanchinoside R1 |
Molecular Weight | 933.13 |
Formula | C47H80O18 |
Cas No. | 80418-24-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | H2O: 2.5 mg/mL (2.68 mM) DMSO: 25 mg/mL (26.79 mM) 10% DMSO+90% Saline: 2.5 mg/mL (2.68 mM), Working solution is recommended to be prepared and used immediately. | ||||||||||
Solution Preparation Table | |||||||||||
H2O/10% DMSO+90% Saline/DMSO
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