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JBSNF-000088 (Synonyms: JBSNF000088)

Name: JBSNF-000088
Brand: TargetMol
SKU: T8106
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T8106 Copy Product Info

Purity: 99.85%

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JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.

JBSNF-000088

Copy Product Info

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Catalog No. T8106

Synonyms JBSNF000088

JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.

Cas No. 7150-23-4

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Pack Size	Price	USA Stock	Global Stock
50 mg	$30	In Stock	In Stock
100 mg	$39	In Stock	In Stock
200 mg	$55	In Stock	In Stock
500 mg	$91	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.85%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

JBSNF-000088 AI Summary

JBSNF-000088 exhibits inhibitory bioactivity against Nicotinamide N-methyltransferase (NNMT) with varying IC50 values depending on the assay and species. It inhibits human NNMT with an IC50 value of 2365.0 nM as determined by a fluorescence assay following a preincubation at a concentration of 30 μM for 30 minutes and subsequent measurement after 60 minutes. In another luminescence-based methyltransferase assay, it shows an IC50 of 1388.0 nM measured after 20 minutes. Additionally, the compound displays a range of potency in inhibiting NNMT across human, monkey, and mouse enzymes, as well as endogenous NNMT overexpressed in various cell lines, with IC50 values spanning from 1600.0 nM to 6300.0 nM. These findings suggest that JBSNF-000088 could be a promising candidate for further investigation in targeted therapies involving NNMT..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.
Targets&IC50	NNMT (mouse):5.0 µM (IC50), NNMT (monkey):2.8 µM (IC50), NNMT (human):1.8 µM (IC50)
Synonyms	JBSNF000088

Chemical Properties

Molecular Weight	152.15
Formula	C₇H₈N₂O₂
Cas No.	7150-23-4
Smiles	C(N)(=O)C=1C=CC(OC)=NC1
Relative Density.	1.213 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (328.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc