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Anti-CD146/MCAM Antibody-PE (8V819)
🥰Excellent
Catalog No. TMAY-00295P
Anti-CD146/MCAM Antibody-PE (8V819) is a PE-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-PE (8V819) can be used in FCM.
Anti-CD146/MCAM Antibody-PE (8V819)
Anti-CD146/MCAM Antibody-PE (8V819)
🥰Excellent
Catalog No. TMAY-00295P
Anti-CD146/MCAM Antibody-PE (8V819) is a PE-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-PE (8V819) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD146/MCAM Antibody-PE (8V819) is a PE-conjugated Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody-PE (8V819) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8V819 |
| Reactivity | Human |
| Verified Activity | 1. Profile of anti-CD146 reactivity on HeLa cells analyzed by flow cytometry. 2. Immunofluorescence staining of Human CD146 in Hela cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human CD146 monoclonal antibody (PE-conjugated, 10 µg/ml) at 4°C overnight, and counterstained with DAPI (blue). Positive staining was localized to plasma membrane. |
| Application | FCM |
| Recommended Dose | 2 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD146 / MCAM (rh CD146; TMPY-01034; NP_006491.2; Met 1-Gly 559) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.1% sodium azide |
| Research Background | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/HRP |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD146 protein (TMPY-01034) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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