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Anti-PINK1 Antibody (1K285) (Synonyms: Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putat...)
Catalog No. TMAB-01541 Copy Product Info
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Anti-PINK1 Antibody (1K285) is a Mouse antibody targeting PINK1. Anti-PINK1 Antibody (1K285) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-PINK1 Antibody (1K285)
Copy Product Info🥰Excellent
Catalog No. TMAB-01541
Synonyms Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK
Anti-PINK1 Antibody (1K285) is a Mouse antibody targeting PINK1. Anti-PINK1 Antibody (1K285) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB.
Anti-PINK1 Antibody
(1K285)
(1K285)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $488 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-PINK1 Antibody (1K285) is a Mouse antibody targeting PINK1. Anti-PINK1 Antibody (1K285) can be used in ICC/IF, IF, IHC-Fr, IHC-P, WB. |
| Synonyms | Serine/Threonine-Protein Kinase PINK1, Mitochondrial, PTEN-Induced Putative Kinase Protein 1, PTEN Induced Putative Kinase 1, Protein Kinase BRPK, PINK 1, Parkinson Disease(Autosomal Recessive) 6, PARK6, EC 2.7.11.1, BRPK |
| Ig Type | IgG |
| Clone | 1K285 |
| Reactivity | Human,Mouse |
| Verified Activity | All Lanes: Anti-Pink1 (115-213) at 1:4000 dilution Lane 1: A431 whole cell lysate Lane 2: Mouse brain lysate Lysates/proteins at 20 μg per Lane. Secondary: Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 63 kDa Blocking/Dilution buffer: 5% NFDM/TBST.  |
| Application | |
| Recommended Dose | ICC/IF=1:100-500; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; WB=1:500-5000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] |
| Immunogen | Recombinant Protein: human PINK1 protein |
| Antigen Species | Human |
| Gene Name | PINK1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase PINK1, mitochondrial |
| Uniprot ID | |
| Biology Area | Cardiac metabolism,Mitochondrial markers,Mitophagy fission and fusion,Neurodegenerative disease,Parkinson's disease,Mitochondrial,Other Kinases |
| Function | Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN . Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 . Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form . Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). |
| Molecular Weight | Theoretical: 63 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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