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Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2
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Catalog No. TMAB-10341
Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Ataxin 1 (Ser775). Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2
Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2
😃Good
Catalog No. TMAB-10341
Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Ataxin 1 (Ser775). Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Ataxin 1 (Ser775). Anti-Phospho-Ataxin 1 (Ser775) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Note=Colocalizes with USP7 in the nucleus. |
| Tissue Specificity | Widely expressed throughout the body. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). |
| Immunogen | KLH conjugated synthesised phosphopeptide: human Ataxin 1 around the phosphorylation site of Ser776 |
| Antigen Species | Human |
| Gene Name | ATXN1 |
| Gene ID | |
| Protein Name | Ataxin-1 |
| Uniprot ID | |
| Function | Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function. |
| Molecular Weight | Theoretical: 87 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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