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ABR-238901

Catalog No. T39115 CAS 1638200-22-2

ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential as a compound for the treatment of myocardial infarction (MI).

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ABR-238901, CAS 1638200-22-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 125.00
5 mg	In stock	$ 313.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 788.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,480.00
1 mL * 10 mM (in DMSO)	In stock	$ 345.00

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Purity: 99.15%

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Description

In vivo

ABR-238901, given at a dose of 30 mg/kg/day through gavage over a period of 3 weeks, demonstrates reduced angiogenesis and lowered levels of IL6 and IL10 in MDSCs [1]. When ABR-238901 (30 mg/kg/day via gavage) is combined with Bortezomib (0.6 mg/kg via subcutaneous injection, twice a week), it leads to a decreased tumor burden compared to using either agent alone [1]. In C57BL/6NRJ mice with myocardial ischemia resulting from permanent coronary artery ligation, ABR-238901 administered at a dose of 30 mg/kg via intraperitoneal injection for the initial 3 days, followed by continuous oral administration daily for 21 days, induces progressive deterioration of cardiac function and accelerates left ventricular remodeling. However, when ABR-238901 is administered during the first 3 days post-myocardial infarction, it limits inflammatory damage and promotes a reparative environment [2].

Molecular Weight	394.63
Formula	C11H9BrClN3O4S
CAS No.	1638200-22-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 0.1 mg/mL (insoluble), Sonification and heating to 60℃ are recommended.

DMSO: 30.0 mg/mL (76.0 mM), Sonification and heating to 60℃ are recommended.

References and Literature

1. Kim De Veirman, et al. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res. 2017 Oct;5(10):839-846. 2. Goran Marinković, et al. S100A9 Links Inflammation and Repair in Myocardial Infarction. Circ Res. 2020 Aug 14;127(5):664-676. 3. A. Schiopu, et al. Short-term blockade of the S100A8/A9 alarmin in the immediate post-myocardial infarction period inhibits acute myocardial inflammation and preserves myocardial repair. European Heart Journal,2017;38(1).

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max PPI Inhibitor Library

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Keywords

ABR-238901 1638200-22-2 Immunology/Inflammation TLR ABR238901 ABR 238901 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.