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Acarbose

Name: Acarbose
Brand: TargetMol
SKU: T0247
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0247Cas No. 56180-94-0

Alias BAY g 5421

Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). Acarbose enhances the hypoglycemic effect of sulfonylureas or insulin.

Acarbose

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Purity: 99.88%

Catalog No. T0247Alias BAY g 5421Cas No. 56180-94-0

Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). Acarbose enhances the hypoglycemic effect of sulfonylureas or insulin.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$65	In Stock	In Stock
1 g	$79	In Stock	In Stock
5 g	$187	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.88%

Color:White

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Product Introduction

Bioactivity

Description	Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). Acarbose enhances the hypoglycemic effect of sulfonylureas or insulin.
Targets&IC50	α-glucosidase:11 nM, maltose (1 g/l):36 μg/ml, sucrose (4 g/l):3.2 μg/ml, maltose (2 g/l):57 μg/ml, Caco-2 cells:5 μM, α-glucosidase:2.154 µg/mL
In vitro	METHODS: A7r5 cells pretreated with TNF-α were treated with Acarbose (1, 2, and 3 μM) and the expression levels of target proteins were detected by Western Blot. RESULTS: Acarbose decreased the expression of β-galactosidase and Ras and increased the expression of p-AMPK in a dose-dependent manner. [1]
In vivo	METHODS: To study the hypoglycemic effect of Acarbose, rats were treated with Acarbose (30, 60 mg/kg) by gavage once daily for 8 weeks. RESULTS: Acarbose reduced fasting glucose and modulated glucose tolerance without weight loss in DM rats. Acarbose significantly inhibited serum IL6 and TNF-α in DM rats. [2] METHODS: To study the effect of Acarbose on atherosclerosis, rabbits were fed Acarbose (2.5-5.0 mg/kg) for 25 weeks. RESULTS: Acarbose significantly and dose-dependent reduced the intensity of IL-6, TNF-α and iNOS staining, and significantly increased the intensity of p-AMPK staining in the neointima. Acarbose significantly and dose-dependent reduced neointimal Ras and β-galactosidase expression in HCD-fed rabbits without weight loss. [1]
Cell Research	Cell viability is determined using the MTT assay. Cells are seeded in 24-well culture plates at a density of 2×104 cells/well, incubated for 48 h, treated with acarbose at varying concentrations (0.5, 1.0, 2.0, 3.0, and 5.0 μM) for 24 h; or pre-treated with TNF-α (20 ng/mL) for either 24 h or 48 h to evaluate the dose-dependent effects of acarbose on VSMC growth and viability, cultured with 0.5 mg/mL MTT at 37°C in a humidified atmosphere of 5% CO2 for another 4 h, and solubilized with isopropanol. The viable cell number varies directly with the concentration of formazan product measured spectrophotometrically at 563 nm.
Synonyms	BAY g 5421

Chemical Properties

Molecular Weight	645.6
Formula	C₂₅H₄₃NO₁₈
Cas No.	56180-94-0
Smiles	O([C@@H]1[C@@H](CO)O[C@H](O[C@@H]([C@@H]([C@H](C=O)O)O)[C@@H](CO)O)[C@H](O)[C@H]1O)[C@@H]2[C@H](O)[C@@H](O)[C@H](N[C@H]3C=C(CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](C)O2
Relative Density.	1.4278 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (77.45 mM), Sonication is recommended.

H2O: 64.50 mg/mL (99.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5489 mL	7.7447 mL	15.4895 mL	77.4473 mL
5 mM	0.3098 mL	1.5489 mL	3.0979 mL	15.4895 mL
10 mM	0.1549 mL	0.7745 mL	1.5489 mL	7.7447 mL
20 mM	0.0774 mL	0.3872 mL	0.7745 mL	3.8724 mL
50 mM	0.0310 mL	0.1549 mL	0.3098 mL	1.5489 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc