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Anti-PKM Antibody (4D256)
(Synonyms: THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP) Copy Product Info
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Synonyms: THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP
Catalog No. TMAH-00983 Copy Product Info
🥰Excellent
Anti-PKM Antibody (4D256) is a Mouse antibody targeting PKM. Anti-PKM Antibody (4D256) can be used in ELISA,FCM,IF,IHC,IP,WB.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $347 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-PKM Antibody (4D256) is a Mouse antibody targeting PKM. Anti-PKM Antibody (4D256) can be used in ELISA,FCM,IF,IHC,IP,WB. |
| Synonyms | THBP1, TCB, pyruvate kinase, muscle, PKM2, PK3, OIP3, HEL-S-30, CTHBP |
| Ig Type | IgG1 |
| Clone | 4D256 |
| Reactivity | Human, Rat, Mouse, Rabbit |
| Application | |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Purity | >95% |
| Research Background | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. In addition to its role in glycolysis, also regulates transcription. Stimulates POU5F1-mediated transcriptional activation. Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages. Also acts as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs. Plays a general role in caspase independent cell death of tumor cells. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human Pyruvate kinase PKM Protein (2-531AA) |
| Antigen Species | Human |
| Gene Name | PKM |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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