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Liriodenine is a natural alkaloid that induces apoptosis in various cancer cells by targeting caspase-3 and caspase-9, and exhibits antimicrobial, antifungal, antitumour, antiviral, and antiplatelet aggregation activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $429 | In Stock | |
5 mg | $2,049 | Backorder |
Description | Liriodenine is a natural alkaloid that induces apoptosis in various cancer cells by targeting caspase-3 and caspase-9, and exhibits antimicrobial, antifungal, antitumour, antiviral, and antiplatelet aggregation activities. |
Targets&IC50 | HT-29 cells:11.02 μM, MLKL (HT-29 cells):11.02 μM, HEK-293 cells:8.07μM, KB cells:9.60 μM, A549 cells:9.20 μM |
In vitro | Methods: Liriodenine (0.16-20 μg/mL, 48 hours) was used to treat human oral epidermoid carcinoma (KB), human colon cancer (Col-2 and HT-29), human breast cancer (MCF-7), human lung cancer (Lu-1 and A549), rat glioma (ASK), and noncancerous human embryonic kidney cells (HEK-293), and cytotoxicity was determined using the sulforhodamine B assay. Results: Liriodenine showed IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07 μM for KB, HT-29, MCF-7, A549, ASK, and HEK-293 cells, respectively. [2] |
In vivo | Methods: Liriodenine (0.01, 0.1 mg/kg, intravenous) was administered to rats to determine whether the effective antiarrhythmic dose of 0.01 mg/kg liriodenine has an effect on left ventricular (LV)-arterial coupling in Wistar rats. Results: Liriodenine at a dose of 0.01 mg/kg did not cause significant changes in basal heart rate (HR), cardiac output (CO), LV end-systolic pressure (Pes), Ea, Ees, and Q load, whereas liriodenine at a dose of 0.1 mg/kg caused a significant decrease in HR by 2.0%, a significant increase in CO by 5.8%, but no significant change in Pes. In addition, administration of 0.1 mg/kg liriodenine to rats significantly decreased Ees by 8.5% and Ea by 10.6%, but did not change Q load. [3] |
Alias | VLT045, Spermatheridine |
Molecular Weight | 275.26 |
Formula | C17H9NO3 |
Cas No. | 475-75-2 |
Smiles | O=C1C2=NC=CC3=CC=4OCOC4C(C=5C=CC=CC15)=C32 |
Relative Density. | 1.501g/cm3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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