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Teniposide

Name: Teniposide
Brand: TargetMol
SKU: T1523
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1523Cas No. 29767-20-2

Alias VM26, NSC 122819

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

Teniposide

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Purity: 99.45%

Catalog No. T1523Alias VM26, NSC 122819Cas No. 29767-20-2

Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$36	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$90	In Stock	In Stock
100 mg	$146	In Stock	In Stock
500 mg	$393	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.45%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Teniposide AI Summary

Teniposide exhibits moderate lipophilicity with a LogP value of 2.8 and a LogD7.4 value of 1.22, indicating potential for good brain penetration given its capillary permeability of 2E-7 cm/s in rat brain. The compound displays notable cytotoxic activity against various cancer cell lines, including an IC50 of 220.0 nM against RPMI8402 lymphoblast tumor cells and 125.0 nM against MCF7 breast cancer cells. It affects vincristine-resistant CCRF-CEM cells, with a Log CR value of 1.56, and shows strong antiproliferative activity against human PC3, MCF7, and A549 cells, with an IC50 of 15.8 nM. Furthermore, Teniposide inhibits DNA topoisomerase I and II-mediated DNA cleavage with greater potency than topotecan and VM26, respectively. It has a clearance rate of 0.19 mL/min/kg, a volume of distribution at steady state of 0.41 L/kg, and a half-life of 16.0 hours in humans. The compound shows involvement with transporters like P-glycoprotein (P-gp), MRP2, and BCRP, indicating potential challenges with efflux and bioavailability. While Teniposide displays moderate liver toxicity (elevated ALT or AST levels in clinical chemistry results), it generally does not induce severe liver injury or acute hepatotoxicity. Additionally, the compound inhibits SARS-CoV-2 3CL-Pro protease by 15.66% at 20μM and shows some antiviral activity against SARS-CoV-2 in VERO-6 cells. Overall, Teniposide demonstrates a diverse bioactivity profile, including significant anticancer properties, moderate liver toxicity, involvement in drug resistance mechanisms, and limited antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.
Synonyms	VM26, NSC 122819

Chemical Properties

Molecular Weight	656.65
Formula	C₃₂H₃₂O₁₃S
Cas No.	29767-20-2
Smiles	O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@@H](OC5)C6=CC=CS6)[H])[H])[C@]2(CO1)[H])=CC7=C(C3)OCO7)C8=CC(OC)=C(O)C(OC)=C8)[H]
Relative Density.	1.2568 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 125 mg/mL (190.36 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.05 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5229 mL	7.6144 mL	15.2288 mL	76.1441 mL
5 mM	0.3046 mL	1.5229 mL	3.0458 mL	15.2288 mL
10 mM	0.1523 mL	0.7614 mL	1.5229 mL	7.6144 mL
20 mM	0.0761 mL	0.3807 mL	0.7614 mL	3.8072 mL
50 mM	0.0305 mL	0.1523 mL	0.3046 mL	1.5229 mL
100 mM	0.0152 mL	0.0761 mL	0.1523 mL	0.7614 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc