Multi-kinase-IN-7

Name: Multi-kinase-IN-7
Brand: TargetMol
SKU: T213692
Rating: 4.5 (1 reviews)

Catalog No. T213692 Copy Product Info

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Multi-kinase-IN-7 is a multi-kinase inhibitor with IC50 values of 2.19, 2.95, 3.59, and 9.31 μM against EGFR, VEGFR2, TrKA, and CDK2, respectively. It demonstrates moderate to weak activity on FAK, AKT1, GSK3β, and CDK5, with IC50 values of 6.3, 9.2, 11.7, and 23.4 μM, respectively. Multi-kinase-IN-7 exhibits broad-spectrum antiproliferative potential against NCI cancer cell lines and can induce cell cycle arrest, apoptosis (apoptosis), and necrosis. MDA-MB-231 is applicable in breast cancer research.

Multi-kinase-IN-7

Copy Product Info

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Catalog No. T213692

Multi-kinase-IN-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Multi-kinase-IN-7 is a multi-kinase inhibitor with IC50 values of 2.19, 2.95, 3.59, and 9.31 μM against EGFR, VEGFR2, TrKA, and CDK2, respectively. It demonstrates moderate to weak activity on FAK, AKT1, GSK3β, and CDK5, with IC50 values of 6.3, 9.2, 11.7, and 23.4 μM, respectively. Multi-kinase-IN-7 exhibits broad-spectrum antiproliferative potential against NCI cancer cell lines and can induce cell cycle arrest, apoptosis (apoptosis), and necrosis. MDA-MB-231 is applicable in breast cancer research.
Targets&IC50	EGFR:2.19 μM
In vitro	Multi-kinase-IN-7 (Compound 12b) exhibits broad-spectrum antiproliferative potential against NCI cancer cell lines at concentrations ranging from 0.01 to 100 μM over 24 hours, with an average GI50 of 10.63 μM. It shows significant antiproliferative activity specifically against all breast cancer cell lines, with GI50 values between 4.03 and 15.3 μM. At 15.3 μM over 48 hours, Multi-kinase-IN-7 induces cell cycle arrest at the G2/M phase in MDA-MB-231 cells and significantly promotes apoptosis (via the mitochondrial pathway) and necrosis.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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