ADC Linker

Fmoc-PEA (Example 1-2) is utilized as a cleavable linker for antibody-drug conjugates (ADC).

Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070.This compound is unstable in powder form and other related salt forms are recommended.

DOTA-NHS-ester is a linker of affibody molecules for small animal PET, SPECT, and CT, and it can be used to label radiotherapeutic agents or imaging probes for tumor detection.

SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.

DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

N3-C3-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

DTSSP Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker.

SPP is a cleavable linker that can be used to form antibody-coupled compounds with therapeutic effects on cancer.

Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable it to specifically react with primary amines and sulfhydryl groups, respectively.

DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable linker used in the production of antibody-drug conjugates (ADCs), enabling the attachment of cytotoxic drugs to antibodies for targeted delivery [1].

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.

BS3 Crosslinker disodium, a non-cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs).

Gly-Gly-Gly-PEG4-DBCO is a cleavable tetraethylene glycol (PEG) linker with four units, primarily used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

TCO-PEG4-NHS ester is a PROTAC linker bridge in the PEG class, used for synthesizing various PROTAC molecules. As a cleavable and synthetic ADC, it is also utilized in the synthesis of antibody-drug conjugates (ADCs).

MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).

Propargyl-C1-NHS ester (4-Pentynoic Acid Succinimidyl Ester) is a nonclaevable linker used for antibody-drug-conjugation (ADC).

DSP Crosslinker, used in antibody-drug conjugates (ADCs) synthesis, is a cleavable ADC linker[1].

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).

Aminooxy-PEG3-azide is an ADC linker belonging to the class of PEGs, as well as three-unit PEGs, which can be used for the synthesis of antibody-coupled reactive molecules (ADCs).

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.

N3-C5-NHS ester, a noncleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).

PC Biotin-PEG3-alkyne is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could activate equal amounts of anti-CD11

MC-Gly-Gly-Phe-Gly (DSN28369) is a heterobifunctional linker, and useful to make antibody drug conjuate (ADC).

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].

m-PEG8-NHS ester is an 8-unit PEG-containing ADC linker that can be used to synthesize antibody-coupled reactive molecules (ADCs), which can be used to modify proteins and peptides.

N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It exhibits antibacterial activity and is employed in antibacterial biofilm[1].

FMOC-3VVD-OH is an active chemical.

SPDMV is a PEG-based ADC linker involved in the synthesis of antibody-coupled reactive molecules (ADCs).

Bis-PEG3-NHS ester is a noncleavable 3-unit PEG linker used in antibody-drug conjugation (ADC).

Azide-C2-SS-C2-biotin is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Aloe vera has anti-inflammatory, antimicrobial, antioxidant and wound healing properties and can be used to study skin damage and GERD.

Boc-Dap-NE used in the synthesis of antibody-drug conjugates (ADCs).It is a cleavable ADC linker

N3-PEG4-C2-NHS ester is a noncleavable, four-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs).

Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Fmoc-Val-Ala-PAB-OH (Fmoc-Val-Ala-PAB) is a useful linker for making Antibody-Drug-Conjugation (ADC) conjugate for targeting drug delivery. It is also utilized in the synthesis of RGD peptidomimetic-paclitaxel conjugates bearing lysosomally cleavable linkers.

Fmoc-Val-Cit-PAB-PNP is a linker used in Antibody-Drug Conjugation (ADC).

Fmoc-Gly-Gly-OH, a cleavable ADC linker, can be used in the synthesis of antibody-drug conjugates (ADCs).

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-Lys-OH hydrochloride is an alkyl-chain-based PROTAC linker and a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

NH-bis(C1-Boc) is an uncleavable linker used for antibody-drug conjugates (ADC).

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Boc-Val-Cit-OH is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].