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Slingshot inhibitor D3

Name: Slingshot inhibitor D3
Brand: TargetMol
SKU: T28804
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28804Cas No. 1715076-35-9

Alias JHN76359

Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.

Slingshot inhibitor D3

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Purity: 97.87%

Catalog No. T28804Alias JHN76359Cas No. 1715076-35-9

Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$59	In Stock
10 mg	$94	In Stock
25 mg	$188	In Stock
50 mg	$296	In Stock
100 mg	$447	In Stock
200 mg	$632	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock

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Purity:97.87%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.
Targets&IC50	SSH:3 Μm(Slingshot 1 ), SSH:3.9 μM (Ki; Slingshot 2)
In vitro	Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2.
In vivo	Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot.
Synonyms	JHN76359

Chemical Properties

Molecular Weight	461.55
Formula	C₂₅H₁₉NO₄S₂
Cas No.	1715076-35-9
Smiles	Cc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 23.08 mg/mL (50 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1666 mL	10.8331 mL	21.6661 mL	108.3306 mL
5 mM	0.4333 mL	2.1666 mL	4.3332 mL	21.6661 mL
10 mM	0.2167 mL	1.0833 mL	2.1666 mL	10.8331 mL
20 mM	0.1083 mL	0.5417 mL	1.0833 mL	5.4165 mL
50 mM	0.0433 mL	0.2167 mL	0.4333 mL	2.1666 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc