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Slingshot inhibitor D3

Name: Slingshot inhibitor D3
Brand: TargetMol
SKU: T28804
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28804Cas No. 1715076-35-9

Alias JHN76359

Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.

Slingshot inhibitor D3

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Purity: 97.87%

Catalog No. T28804Alias JHN76359Cas No. 1715076-35-9

Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$268	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:97.87%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Slingshot inhibitor D3 (JHN76359) is a potent inhibitor of the Protein Phosphatase Slingshot.
Targets&IC50	SSH:3 Μm(Slingshot 1 ), SSH:3.9 μM (Ki; Slingshot 2)
In vitro	Slingshot 1 had?IC50?value of 3 μM and Slingshot 2 had?Ki value of 3.9 μM.?Slingshot inhibitor D3 has similar inhibitory activitieswith Slingshot 1 and Slingshot 2.
In vivo	Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes. Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation. Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot.
Synonyms	JHN76359

Chemical Properties

Molecular Weight	461.55
Formula	C₂₅H₁₉NO₄S₂
Cas No.	1715076-35-9
Smiles	Cc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 23.08 mg/mL (50.01 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1666 mL	10.8331 mL	21.6661 mL	108.3306 mL
5 mM	0.4333 mL	2.1666 mL	4.3332 mL	21.6661 mL
10 mM	0.2167 mL	1.0833 mL	2.1666 mL	10.8331 mL
20 mM	0.1083 mL	0.5417 mL	1.0833 mL	5.4165 mL
50 mM	0.0433 mL	0.2167 mL	0.4333 mL	2.1666 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc