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CASIN

Name: CASIN
Brand: TargetMol
SKU: T3971
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3971Cas No. 425399-05-9

Alias Pirl1-related Compound 2

CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).

CASIN

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Purity: 99.89%

Catalog No. T3971Alias Pirl1-related Compound 2Cas No. 425399-05-9

CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$68	In Stock
10 mg	$123	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$458	In Stock
500 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock

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Batch Information

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Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
Targets&IC50	GTPase CDC42:2 μM
In vitro	CASIN (5 uM) could reduce the elevated level of active Cdc42 in aged primitive hematopoietic cells to the level in young cells.
In vivo	CASIN can reverse the aging-related and polarity phenotype of aged HSCs to that of young HSCs.
Synonyms	Pirl1-related Compound 2

Chemical Properties

Molecular Weight	306.4
Formula	C₂₀H₂₂N₂O
Cas No.	425399-05-9
Smiles	OCCNC1CCCc2c1[nH]c1ccc(cc21)-c1ccccc1
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (179.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2637 mL	16.3185 mL	32.6371 mL	163.1854 mL
5 mM	0.6527 mL	3.2637 mL	6.5274 mL	32.6371 mL
10 mM	0.3264 mL	1.6319 mL	3.2637 mL	16.3185 mL
20 mM	0.1632 mL	0.8159 mL	1.6319 mL	8.1593 mL
50 mM	0.0653 mL	0.3264 mL	0.6527 mL	3.2637 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	1.6319 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc