mGluR1activator-1 is a stable vitamin K analog and mGluR1 activator capable of crossing the blood-brain barrier. It strongly activates transcription through steroid and xenobiotic receptors and retinoic acid receptors, effectively inducing neurogenesis in neural progenitor cells in mice. mGluR1activator-1 is applicable in studying neurodegenerative diseases, such as Alzheimer's.

mGluR1 activator-1 (Compound 7) at concentrations of 1-10 μM over 48 hours modulates transcriptional activity through SXR and RAR in neural stem cells. At 1 μM for 48 hours, it significantly increases Map2 positive signaling, indicating effective induction of neural progenitor cells into neurons. Furthermore, mGluR1 activator-1 (1-10 μM) enhances cellular uptake in MG63 cells in a concentration-dependent manner within 24 hours and is subsequently converted into the bioactive form Menaquinone-4 (MK-4).

Compound 7, known as mGluR1 activator-1, when administered orally at a concentration of 10 μmol/mL (single dose), enters the brain of C57BL6J mice more rapidly than MK-4 and subsequently converts to MK-4 within 24 hours post-administration.