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Indazole

Name: Indazole
Brand: TargetMol
SKU: T2192
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2192Cas No. 271-44-3

Indazole is also called benzpyrazole or isoindazone. Its derivatives exhibit a wide range of biological activities. Indazole and its derivatives can be used in the research of cancer, neurological diseases, cardiovascular diseases, and gastrointestinal diseases.

Indazole

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Purity: 99.85%

Catalog No. T2192Cas No. 271-44-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Indazole AI Summary

Indazole demonstrates a partition coefficient (logP) of 1.82 and a distribution coefficient (LogD7.4) of 1.9, suggesting moderate hydrophobicity. The compound has a dissociation constant (Kd) of 10,000 nM when binding to CDK2/Cyclin A, and an IC50 value of 185,000 nM for inhibiting CDK2 in radiometric assays. It also shows significant enzyme inhibition properties, including an IC50 value of 178,000 nM against recombinant NOS1 and varying inhibition percentages across multiple kinases (e.g., AurA, AurB, and ROCK1). Specifically, it displaces Y-27632 from ROCK-1 with over 80% activity and binds to human HSP90alpha with a moderate affinity (Kd = 5300 nM). Furthermore, Indazole inhibits iNOS and nNOS in LPS-stimulated Wistar rat models and binds to both ferric and ferrous states of IDO1, although it demonstrates relatively weak inhibitory activity against IDO1 and SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	118.14
Formula	C₇H₆N₂
Cas No.	271-44-3
Smiles	N1C=C2C=CC=CC2=N1
Relative Density.	1.242 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (190.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (16.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.4645 mL	42.3227 mL	84.6453 mL	423.2267 mL
5 mM	1.6929 mL	8.4645 mL	16.9291 mL	84.6453 mL
10 mM	0.8465 mL	4.2323 mL	8.4645 mL	42.3227 mL
20 mM	0.4232 mL	2.1161 mL	4.2323 mL	21.1613 mL
50 mM	0.1693 mL	0.8465 mL	1.6929 mL	8.4645 mL
100 mM	0.0846 mL	0.4232 mL	0.8465 mL	4.2323 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc