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GC7 Sulfate

Name: GC7 Sulfate
Brand: TargetMol
SKU: T11372
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11372Cas No. 150417-90-6

GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.

GC7 Sulfate

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Purity: 99.85%

Catalog No. T11372Cas No. 150417-90-6

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$297	In Stock	In Stock
100 mg	$478	In Stock	In Stock
500 mg	$1,050	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA IC FNMR HPLC HNMR

Product Introduction

Bioactivity

Description	GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
Targets&IC50	S1P1:10 nM(ki)
In vitro	Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug[1].

Chemical Properties

Molecular Weight	270.35
Formula	C₈H₂₂N₄O₄S
Cas No.	150417-90-6
Smiles	O=S(=O)(O)O.N=C(N)NCCCCCCCN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 90 mg/mL (332.9 mM), Sonication and heating are recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6989 mL	18.4945 mL	36.9891 mL	184.9454 mL
5 mM	0.7398 mL	3.6989 mL	7.3978 mL	36.9891 mL
10 mM	0.3699 mL	1.8495 mL	3.6989 mL	18.4945 mL
20 mM	0.1849 mL	0.9247 mL	1.8495 mL	9.2473 mL
50 mM	0.0740 mL	0.3699 mL	0.7398 mL	3.6989 mL
100 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc