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GC7 Sulfate

Name: GC7 Sulfate
Brand: TargetMol
SKU: T11372
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11372Cas No. 150417-90-6

GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.

GC7 Sulfate

🥰Excellent

Purity: 99.85%

Catalog No. T11372Cas No. 150417-90-6

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$89	In Stock
25 mg	$197	In Stock
50 mg	$297	In Stock
100 mg	$478	In Stock
500 mg	$1,050	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.85%

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COA HPLC IC HNMR FNMR

Product Introduction

Bioactivity

Description	GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
Targets&IC50	S1P1:10 nM(ki)
In vitro	Cell cycle analysis show that GC7 Sulfate reduces the CHO-K1 cell population in the G1-phase of the cell cycle by 42% and increases the number of cells in the S-phase by 44%. Furthermore, GC7 Sulfate inhibited the growth of H9 cells in a concentration-dependent manner. While 1 μM GC7 Sulfate had no significant effect on H9 cell proliferation, inhibition of growth became evident with 3 μM GC7 Sulfate. At 10 μM GC7 Sulfate, H9 cell growth was completely blocked within 1 or 2 days after the addition of the drug[1].

Chemical Properties

Molecular Weight	270.35
Formula	C₈H₂₂N₄O₄S
Cas No.	150417-90-6
Smiles	O=S(=O)(O)O.N=C(N)NCCCCCCCN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 90 mg/mL (332.9 mM), Sonication and heating are recommended.

DMSO: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.6989 mL	18.4945 mL	36.9891 mL	184.9454 mL
5 mM	0.7398 mL	3.6989 mL	7.3978 mL	36.9891 mL
10 mM	0.3699 mL	1.8495 mL	3.6989 mL	18.4945 mL
20 mM	0.1849 mL	0.9247 mL	1.8495 mL	9.2473 mL
50 mM	0.0740 mL	0.3699 mL	0.7398 mL	3.6989 mL
100 mM	0.0370 mL	0.1849 mL	0.3699 mL	1.8495 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc