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Seneciphylline
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Catalog No. TN1078Cas No. 480-81-9
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduction of cytochrome P-450 and related monooxygenase activities.
Seneciphylline
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Purity: 99.84%
Catalog No. TN1078Cas No. 480-81-9
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduction of cytochrome P-450 and related monooxygenase activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $143 | In Stock | In Stock | |
| 10 mg | $228 | In Stock | In Stock | |
| 25 mg | $389 | In Stock | In Stock | |
| 50 mg | $572 | In Stock | In Stock | |
| 100 mg | $813 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.84%
Color:White
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Product Introduction
Seneciphylline AI Summary
Seneciphylline demonstrates a multifaceted bioactivity profile. It inhibits HIV1 reverse transcriptase with an IC50 value greater than 200.0 µg/mL, suggesting moderate to weak activity against this enzyme. Additionally, it functions as an inhibitor in various assays, notably targeting Human Jumonji Domain Containing 2E (JMJD2E) and the Vitamin D Receptor (VDR). The compound also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) with potencies of 20,000-23,000 nM.
In terms of antitumor activity, Seneciphylline shows a potency of 100,000 nM (GI50) against several human tumor cell lines, with heightened efficacy against the NCI-H460 Non-Small Cell Lung cell line (GI50 = 84,918.05 nM). It also exhibits growth-inhibitory effects on radicle length in lettuce at 50 µg/cm² and demonstrates toxicity against Chinese hamster ovary cells and fall armyworm Sf9 cells with EC50 values greater than 100.0 µg/mL.
The compound presents antifeedant activity against various insect species and antibacterial activities against pathogens such as Pseudomonas aeruginosa (inhibition rate of 15.22%) and Klebsiella pneumoniae MDR (inhibition rate of 22.67%). However, it displays lower to negative inhibition rates against Escherichia coli, Staphylococcus aureus MRSA, Acinetobacter baumannii, Candida albicans, and Cryptococcus neoformans H99.
Importantly, Seneciphylline shows antiviral activity against SARS-CoV-2 by inhibiting cytotoxic effects in VERO-6 cells at 10 µM concentration, with an IC50 value greater than 20,000.0 nM, indicating moderate efficacy. Overall, the compound displays diverse bioactive properties with varying degrees of efficacy across different biological targets and organisms..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significantly increased the activities of epoxide hydrase and glutathione-S-transferase but cause reduction of cytochrome P-450 and related monooxygenase activities. |
| Molecular Weight | 333.38 |
| Formula | C18H23NO5 |
| Cas No. | 480-81-9 |
| Smiles | [H][C@]12CCN3CC=C(COC(=O)[C@](C)(O)C(=C)C\C(=C\C)C(=O)O1)[C@]23[H] |
| Relative Density. | 1.2467 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.34 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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