Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 143.00 | |
5 mg | In stock | $ 315.00 | |
10 mg | In stock | $ 525.00 | |
25 mg | In stock | $ 849.00 | |
50 mg | In stock | $ 1,170.00 | |
100 mg | In stock | $ 1,580.00 | |
500 mg | In stock | $ 3,170.00 |
Description | Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. |
Targets&IC50 | IGF-1:400 nM, NS3-DNA complex:3.6 μM |
In vitro | Experimentally it is indeed found that AG 538 does not compete with ATP but competes with the IGF-1R substrate. Both AG 538 and I-OMe AG 538 inhibit IGR-1R autophosphorylation in intact cells in a dose-dependent manner. Both compounds inhibit the activation of the downstream targets PKB and Erk2.[1] |
In vivo | Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. FP-based assay was chosen to screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds that inhibit NS3-DNA complex formation. Four LOPAC compounds inhibited the FP-based assay: aurintricarboxylic acid (ATA) (IC50=1.4 μM), suramin sodium salt (IC50=3.6 μM), NF 023 hydrate (IC50=6.2 μM) and tyrphostin AG 538 (IC50=3.6 μM).[2] |
Synonyms | AG 538 |
Molecular Weight | 297.26 |
Formula | C16H11NO5 |
CAS No. | 133550-18-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (10.5 mM)
You can also refer to dose conversion for different animals. More
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Tyrphostin AG 538 133550-18-2 Tyrosine Kinase/Adaptors IGF-1R AG-538 AG 538 AG538 Tyrphostin AG538 Tyrphostin AG-538 inhibitor inhibit