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Tobramycin

Name: Tobramycin
Brand: TargetMol
SKU: T1255
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1255Cas No. 32986-56-4

Alias NSC 180514, Nebramycin Factor 6, Deoxykanamycin B

Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Tobramycin

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Purity: 99.87%

Catalog No. T1255Alias NSC 180514, Nebramycin Factor 6, Deoxykanamycin BCas No. 32986-56-4

Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$106	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Color:White

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Product Introduction

Tobramycin AI Summary

Tobramycin exhibits broad-spectrum antibacterial activity against various bacterial strains, including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii, and Klebsiella pneumoniae, with Minimum Inhibitory Concentrations (MIC) ranging from as low as 0.03 µg/mL to greater than 512 µg/mL depending on the strain and conditions. Notably, it shows significant efficacy against multidrug-resistant strains, indicating its potential usefulness in treating challenging bacterial infections. Additionally, Tobramycin demonstrates specific binding affinities to RNA constructs, inhibiting protein synthesis and other critical bacterial processes, with dissociation constants (Kd) ranging widely from 0.9 nM to 41,430 nM for different RNA targets. It has also shown activity against the Rev-RBE RNA complex, mitochondrial 12S rRNA constructs, and demonstrated in vivo efficacy in mouse infection models. The compound manifests varying degrees of rapidity in its pharmacokinetic parameters, showing a quick absorption rate and substantial initial plasma concentrations. Lastly, while it exhibits promising antibacterial properties, its efficacy is reduced against certain resistant strains, and its activity against biofilms indicates potential utility in more complex bacterial growth scenarios..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.
Synonyms	NSC 180514, Nebramycin Factor 6, Deoxykanamycin B

Chemical Properties

Molecular Weight	467.51
Formula	C₁₈H₃₇N₅O₉
Cas No.	32986-56-4
Smiles	O([C@@H]1[C@@H](O)[C@H](O[C@H]2O[C@H](CN)[C@@H](O)C[C@H]2N)[C@@H](N)C[C@H]1N)[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
Relative Density.	1.52 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (534.75 mM), Sonication is recommended.

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1390 mL	10.6950 mL	21.3899 mL	106.9496 mL
5 mM	0.4278 mL	2.1390 mL	4.2780 mL	21.3899 mL
10 mM	0.2139 mL	1.0695 mL	2.1390 mL	10.6950 mL
20 mM	0.1069 mL	0.5347 mL	1.0695 mL	5.3475 mL
50 mM	0.0428 mL	0.2139 mL	0.4278 mL	2.1390 mL
100 mM	0.0214 mL	0.1069 mL	0.2139 mL	1.0695 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc