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Dimercaprol

Name: Dimercaprol
Brand: TargetMol
SKU: T0781
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0781Cas No. 59-52-9

Alias Dithiopropanol, Dicaptol

Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisonings.

Dimercaprol

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Purity: 99.64%

Catalog No. T0781Alias Dithiopropanol, DicaptolCas No. 59-52-9

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$32	In Stock	In Stock
100 mg	$46	In Stock	In Stock
500 mg	$92	-	In Stock
1 g	$133	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.64%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR

Product Introduction

Dimercaprol AI Summary

Dimercaprol demonstrates a broad spectrum of bioactivities across various biological pathways and targets. It is potent in inhibiting the splicing of Lamin A, HSD17B4 (hydroxysteroid dehydrogenase 4), Tyrosyl-DNA Phosphodiesterase (TDP1), Aldehyde Dehydrogenase 1 (ALDH1A1), HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II), GCN5L2, Histone Lysine Methyltransferase G9a, 15-hLO-2 (15-human lipoxygenase 2), Vitamin D Receptor (VDR), and Glutaminase (GLS). Additionally, it shows inhibitory effects on Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase), Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), Human Flap endonuclease 1 (FEN1), and TGF-b. It also impacts the Cytochrome panel assay, particularly p450-cyp1a2, and impairs the function of the Influenza NS1 protein. In cellular models, Dimercaprol has demonstrated activity against the malarial parasite plastid, Lassa Virus, Marburg Virus, and Ebola Virus, as well as in various assays related to Schwann cells. Notably, it identifies gametocytocidal compounds and has dual action in Huntington's disease models. Furthermore, Dimercaprol inhibits NDM-1 (New Delhi metallo-beta-lactamase) with an IC50 value of 10400.0 nM using imipenem as a substrate and is involved in the activation of human PXR, leading to the induction of CYP3A4 with an efficacy of 35.5% and an EC50 value of 50100.0 nM. It exhibits competitive binding affinity to human PXR LBD and an 88.0% efficacy relative to SR12813 in a competitive binding assay. Importantly, Dimercaprol shows no significant impact on liver toxicity parameters, with scores recorded as 0.0 for various hepatic side effects according to the Drug Induced Liver Injury Prediction System (DILIps). Additionally, it exhibits inhibitory activity against various beta-lactamases (L1, CphA, IMP1, NDM1) from Aeromonas hydrophila ATCC 7966, suggesting potential antimicrobial properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisonings.
Synonyms	Dithiopropanol, Dicaptol

Chemical Properties

Molecular Weight	124.22
Formula	C₃H₈OS₂
Cas No.	59-52-9
Smiles	OCC(S)CS
Relative Density.	1.239 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (402.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	8.0502 mL	40.2512 mL	80.5023 mL	402.5117 mL
5 mM	1.6100 mL	8.0502 mL	16.1005 mL	80.5023 mL
10 mM	0.8050 mL	4.0251 mL	8.0502 mL	40.2512 mL
20 mM	0.4025 mL	2.0126 mL	4.0251 mL	20.1256 mL
50 mM	0.1610 mL	0.8050 mL	1.6100 mL	8.0502 mL
100 mM	0.0805 mL	0.4025 mL	0.8050 mL	4.0251 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc