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Progesterone Receptor

The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11q22, it has two isoforms, PR-A and PR-B, that differ in their molecular weight. The PR-B is the positive regulator of the effects of progesterone, while PR-A serve to antagonize the effects of PR-B.

FilterSignaling PathwaysOthersProgesterone Receptor
  • Medroxyprogesterone Acetate
    T126171-58-9
    Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
    • $30
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    TargetMol | Citations Cited
  • Ulipristal acetate
    T2527126784-99-4
    Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception.
    • $45
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  • Mifepristone
    T110284371-65-3
    Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
    • $37
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  • Vilaprisan
    T350541262108-14-4In house
    Vilaprisan (BAY 1002670) is a novel orally available and selective progesterone receptor modulator (SPRM) with antiproliferative activity against uterine fibroids (UF) and can be used for the study of uterine fibroids.
    • $195
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  • Levonorgestrel
    T1263797-63-7
    Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.
    • $42
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  • Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl-
    T60056936345-34-5In house
    Benzonitrile, 4-[[5-cyclopropyl-3-methyl-1-[(methylsulfonyl)methyl]-1H-pyrazol-4-yl]oxy]-2,6-dimethyl- is a progesterone receptor antagonist with antiprogestin effects.
    • $117
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    TargetMol | Inhibitor Sale
  • PF-02413873
    T28362936345-35-6In house
    PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.
    • $34
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  • Medroxyprogesterone
    T5040520-85-4
    Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.
    • $33
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    TargetMol | Citations Cited
  • Ethynodiol diacetate
    T0996297-76-7
    Ethynodiol diacetate (Ethynodiol acetate) is a synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
    • $58
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    TargetMol | Citations Cited
  • Progesterone
    T047857-83-0
    Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
    • $38
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  • Norethindrone
    T151468-22-4
    Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
    • $38
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    TargetMol | Citations Cited
  • Desogestrel
    T681954024-22-5
    Desogestrel (Cerazette) is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
    • $31
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  • Chlormadinone acetate
    T1596302-22-7
    Chlormadinone acetate (Gestafortin) is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
    • $39
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  • Lynestrenol
    T797452-76-6
    Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
    • $35
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  • Estradiol dipropionate
    T2231113-38-2
    Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a synthetic ester, specifically the 3, 17-dipropanoyl ester, of the natural estrogen, estradiol.
    • $47
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  • Norethindrone acetate
    T4059851-98-9
    Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis.
    • $30
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  • Megestrol acetate
    T1284595-33-5
    Megestrol acetate (BDH1298) is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.
    • $45
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  • Etonogestrel
    T256754048-10-1
    Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.
    • $50
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  • Gestodene
    T149060282-87-3
    Gestodene (WL 70) is a progestogen hormonal contraceptive.
    • $42
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  • Dydrogesterone
    T3036152-62-5
    Dydrogesterone is a potent progestogen which can be used in progesterone deficiency studies.
    • $31
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  • Cridanimod
    T531738609-97-1
    Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1 IRF3 route.
    • $30
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  • Nestoron
    T51747759-35-5
    Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
    • $35
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  • U-46619
    T1718956985-40-1
    U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion.
    • $243
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  • Norgestimate
    T753735189-28-7
    Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.
    • $31
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  • Dienogest
    T257765928-58-7
    Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive.
    • $46
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  • Melengestrol acetate
    T618642919-66-6
    Melengestrol acetate is a derivative of progesterone and acts as a corticosteroid hormone. Melengestrol acetate promotes endometrial proliferation delay of menstrual activity and pregnancy maintenance.
    • $42
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  • Nomegestrol acetate
    T839558652-20-3
    Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor
    • $35
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  • Ulipristal
    T6713159811-51-5
    Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.
    • $34
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  • Altrenogest
    T0870850-52-2
    Altrenogest (Allyltrenbolone)(A35957; RU2267), a progestogen, has structural relation with veterinary steroid trenbolone.
    • $45
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  • Drospirenone
    T154167392-87-4
    Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
    • $43
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  • 17α-Hydroxyprogesterone
    T142968-96-2
    17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.
    • $25
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