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Sodium zirconium cyclosilicate
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Catalog No. T78513Cas No. 17141-74-1
Alias UXSi-9
Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia.
Sodium zirconium cyclosilicate
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Purity: 95.00%
Catalog No. T78513Alias UXSi-9Cas No. 17141-74-1
Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $29 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.00%
Appearance:Solid
Color:White
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| Description | Sodium zirconium cyclosilicate (UXSi-9) is a novel selective cation exchanger and a K+ binder that can be used to remove excess K+ from the body and can be used in the treatment of hyperkalemia. |
| In vitro | Sodium zirconium cyclosilicate (ZS-9) is a crystalline, inorganic cation exchanger highly selective for trapping excess monovalent cations, particularly K+ and ammonium ions. Its exchange capacity for divalent ions (e.g., Ca2+ and Mg2+) is less than 0.05 mEq/g, exhibiting over 25-fold greater selectivity for K+ than for Ca2+ or Mg2+ [1]. |
| In vivo | Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily for 5 days) effectively absorbs and eliminates potassium ions in Sprague-Dawley rats, with subsequent recovery in feces [2]. |
| Synonyms | UXSi-9 |
| Molecular Weight | 365.46 |
| Formula | Na2O9Si3Zr |
| Cas No. | 17141-74-1 |
| Smiles | [O-][Si]1(O[Si]([O-])(O[Si]([O-])(O1)[O-])[O-])[O-].[Na+].[Zr+4].[Na+] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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