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OGT-IN-2

🥰Excellent
Catalog No. T9711Cas No. 442665-87-4

OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].

OGT-IN-2

OGT-IN-2

🥰Excellent
Purity: 98.80%
Catalog No. T9711Cas No. 442665-87-4
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$68In StockIn Stock
2 mg$97In StockIn Stock
5 mg$168In StockIn Stock
10 mg$249In StockIn Stock
25 mgPreferentialIn StockIn Stock
50 mgPreferentialIn Stock-
1 mL x 10 mM (in DMSO)$185In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.80%
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Product Introduction

Bioactivity
Description
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1].
Targets&IC50
ncOGT:53 μM, sOGT:30 μM
Chemical Properties
Molecular Weight446.99
FormulaC23H27ClN2O3S
Cas No.442665-87-4
SmilesOC(=O)C1CC(=O)N(CCC23CC4CC(CC(C4)C2)C3)\C(S1)=N\c1ccc(Cl)cc1
Relative Density.1.50 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (223.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2372 mL11.1859 mL22.3719 mL111.8593 mL
5 mM0.4474 mL2.2372 mL4.4744 mL22.3719 mL
10 mM0.2237 mL1.1186 mL2.2372 mL11.1859 mL
20 mM0.1119 mL0.5593 mL1.1186 mL5.5930 mL
50 mM0.0447 mL0.2237 mL0.4474 mL2.2372 mL
100 mM0.0224 mL0.1119 mL0.2237 mL1.1186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

osteoarthritisOGT-IN-2OGTIN2OGT IN 2OGTO-GlcNAc transferase (OGT)mono- acylglycerol acyltransferaseInhibitorinhibitDiglyceride acyltransferaseDiacylglycerol acyltransferasearticular diseasesarticular cartilageAcyltransferaseacyl-CoA:cholesterol acyltransferase
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