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TGFBI Protein, Human, Recombinant (His)
(Synonyms: transforming growth factor, β-induced, 68kDa, transforming growth factor, beta-induced, 68kDa, LCD1, EBMD, CSD3, CSD2, CSD1, CSD, CDGG1, CDG2, CDB1, BIGH3) Copy Product InfoSynonyms: transforming growth factor, β-induced, 68kDa, transforming growth factor, beta-induced, 68kDa, LCD1, EBMD, CSD3, CSD2, CSD1, CSD, CDGG1, CDG2, CDB1, BIGH3
Catalog No. TMPY-01009 Copy Product Info
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $48 | - | In Stock | |
| 10 μg | $75 | - | In Stock | |
| 20 μg | $118 | - | In Stock | |
| 50 μg | $229 | 7-10 days | 7-10 days | |
| 100 μg | $386 | - | In Stock | |
| 200 μg | $660 | 7-10 days | 7-10 days | |
| 500 μg | $1,330 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:86.5%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q15582 |
| Construction | A DNA sequence encoding the extracellular domain of human beta IG-H3 (NP_000349.1) precursor (Met 1-His 683) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Gly 24 |
| Protein Purity | > 75 % as determined by SDS-PAGE https://cdn.targetmol.com/group3/M00/13/6F/CgoaEWZG002EHBh2AAAAAGKTggY188.png |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a sodium citrate buffer system at pH 6. 0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | transforming growth factor, β-induced, 68kDa, transforming growth factor, beta-induced, 68kDa, LCD1, EBMD, CSD3, CSD2, CSD1, CSD, CDGG1, CDG2, CDB1, BIGH3 |
| Research Background |
| Molecular Weight | 74 kDa (predicted); 65 kDa (reducing condition, due to glycosylation) |
| Storage | Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Related Tags: TGFBI Protein, Human, Recombinant (His) chemical structure | TGFBI Protein, Human, Recombinant (His) molecular weight
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