CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM, suitable for use in neurological research [1] [2].

In the mouse visual cortex, CGP 55845 hydrochloride at 1 μM increases the frequency of both spontaneous calcium (Ca2+) transients and inhibitory postsynaptic currents (IPSCs), including miniature IPSCs (mIPSCs), without altering their amplitude or kinetics. Additionally, it significantly elevates the amplitudes of evoked IPSCs (eIPSCs) and reduces the paired-pulse ratio (PPR), indicating a potent effect on synaptic transmission [3].

Administering 0.5 mg/kg of CGP55845 hydrochloride intraperitoneally (i.p.; once) to Cdkl5 KO mice enhances the quantity and density of PSD95-positive puncta, alongside the development and maturation of dendritic spines within the perirhinal cortex (PRC). This treatment also reinstates novel object recognition (NOR) memory. The study utilized 2-month-old male Cdkl5 +/Y and Cdkl5 -/Y mice, observing a notable improvement in NOR memory in the Cdkl5 -/Y mice.