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CGP 55845 hydrochloride
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Catalog No. T21759Cas No. 149184-22-5
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM, suitable for use in neurological research [1] [2].
CGP 55845 hydrochloride
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Catalog No. T21759Cas No. 149184-22-5
CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM, suitable for use in neurological research [1] [2].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $975 | 35 days | 35 days | |
| 50 mg | $4,180 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | CGP55845 hydrochloride is a potent and selective GABAB receptor antagonist with an IC50 of 6 nM, suitable for use in neurological research [1] [2]. |
| In vitro | In the mouse visual cortex, CGP 55845 hydrochloride at 1 μM increases the frequency of both spontaneous calcium (Ca2+) transients and inhibitory postsynaptic currents (IPSCs), including miniature IPSCs (mIPSCs), without altering their amplitude or kinetics. Additionally, it significantly elevates the amplitudes of evoked IPSCs (eIPSCs) and reduces the paired-pulse ratio (PPR), indicating a potent effect on synaptic transmission [3]. |
| In vivo | Administering 0.5 mg/kg of CGP55845 hydrochloride intraperitoneally (i.p.; once) to Cdkl5 KO mice enhances the quantity and density of PSD95-positive puncta, alongside the development and maturation of dendritic spines within the perirhinal cortex (PRC). This treatment also reinstates novel object recognition (NOR) memory. The study utilized 2-month-old male Cdkl5 +/Y and Cdkl5 -/Y mice, observing a notable improvement in NOR memory in the Cdkl5 -/Y mice. |
| Molecular Weight | 438.71 |
| Formula | C18H23Cl3NO3P |
| Cas No. | 149184-22-5 |
| Smiles | Cl.C[C@H](NC[C@H](O)CP(O)(=O)Cc1ccccc1)c1ccc(Cl)c(Cl)c1 |
| Relative Density. | 1.332g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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