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IZCZ-3

Name: IZCZ-3
Brand: TargetMol
SKU: T11698
Rating: 4.5 (1 reviews)

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Catalog No. T11698Cas No. 2223019-53-0

IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.

IZCZ-3

Copy Product Info

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Catalog No. T11698Cas No. 2223019-53-0

IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,230	6-8 weeks	6-8 weeks
50 mg	$1,610	6-8 weeks	6-8 weeks
100 mg	$2,390	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.
In vitro	IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells. IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner.IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1,4.1, and 4.2 μM, respectively).
In vivo	IZCZ-3 inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft.

Chemical Properties

Molecular Weight	715.93
Formula	C₄₆H₄₉N₇O
Cas No.	2223019-53-0
Smiles	CCn1c2ccccc2c2cc(ccc12)-c1nc(c(-c2ccc(cc2)N2CCN(C)CC2)n1-c1ccc(OC)cc1)-c1ccc(cc1)N1CCN(C)CC1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5 mg/mL (6.98 mM), Sonication and heating to 80℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3968 mL	6.9839 mL	13.9678 mL	69.8392 mL
5 mM	0.2794 mL	1.3968 mL	2.7936 mL	13.9678 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc