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TP-238

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Catalog No. T34907Cas No. 2415263-04-4
Alias TP 238

TP-238, a potent and selective dual CECR2/BPTF probe, exhibits IC50 values of 30 nM and 350 nM, respectively. Additionally, it inhibits BRD9 with a pIC50 of 5.9, demonstrating lesser activity against another 338 kinases [1] [2].

TP-238
Other Forms of TP-238:
TP-238 hydrochlorideT400552415263-05-5
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TP-238

😃Good
Catalog No. T34907Alias TP 238Cas No. 2415263-04-4
TP-238, a potent and selective dual CECR2/BPTF probe, exhibits IC50 values of 30 nM and 350 nM, respectively. Additionally, it inhibits BRD9 with a pIC50 of 5.9, demonstrating lesser activity against another 338 kinases [1] [2].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
TP-238, a potent and selective dual CECR2/BPTF probe, exhibits IC50 values of 30 nM and 350 nM, respectively. Additionally, it inhibits BRD9 with a pIC50 of 5.9, demonstrating lesser activity against another 338 kinases [1] [2].
Targets&IC50
CECR2:30 nM, CECR2:10 nM (Kd), CECR2:7.5 (pIC50), BPTF:6.5 (pIC50), BPTF:120 nM (Kd), BPTF:350 nM, BRD9:5.9 (pIC50)
In vitro
TP-238 demonstrates targeted biochemical activity, exhibiting affinities of 10-30 nM with CECR2 and 100-350 nM with BPTF. Furthermore, its potency is confirmed through an Alpha screen assay, with pIC50 values of 7.5 for CECR2 and 6.5 for BPTF, respectively. Isothermal titration calorimetry (ITC) further substantiates TP-238's binding affinity, revealing a dissociation constant (Kd) of 10 nM for CECR2 and 120 nM for BPTF [1] [2].
SynonymsTP 238
Chemical Properties
Molecular Weight458.58
FormulaC22H30N6O3S
Cas No.2415263-04-4
SmilesN(CCCN1C=CC=N1)C2=CC(=NC(S(C)(=O)=O)=N2)C3=CC=C(OCCCN(C)C)C=C3
Relative Density.1.25 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

TP-238TP238
Related Tags: buy TP-238 | purchase TP-238 | TP-238 cost | order TP-238 | TP-238 chemical structure | TP-238 in vitro | TP-238 formula | TP-238 molecular weight
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