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(S)-(+)-Dimethindene maleate

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Catalog No. T23297Cas No. 136152-65-3

(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.

(S)-(+)-Dimethindene maleate
Other Forms of (S)-(+)-Dimethindene maleate:

(S)-(+)-Dimethindene maleate

🥰Excellent
Purity: 99.94%
Catalog No. T23297Cas No. 136152-65-3
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$45-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.94%
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Product Introduction

Bioactivity
Description
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
Targets&IC50
M1 mAChR:7.08 (pKi), H1 Receptor:7.48 (pA2), M2 mAChR:7.78 (pKi), M4 mAChR:7.00 (pKi), M3 mAChR:6.70 (pKi)
In vitro
(S)-(+)-Dimethindene maleate (2 μM; 1 hour) partially reduces the developmental potential of mouse embryonic pluripotent stem (mEPS) cells in chimeric embryos, promoting the rapid differentiation of human pluripotent stem cells (hPSC) into hEPS cells[1].'
Chemical Properties
Molecular Weight408.49
FormulaC24H28N2O4
Cas No.136152-65-3
SmilesOC(=O)\C=C/C(O)=O.C[C@@H](C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (195.84 mM), Sonication is recommended.
H2O: 10 mg/mL (24.48 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.08 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.4480 mL12.2402 mL24.4804 mL122.4020 mL
5 mM0.4896 mL2.4480 mL4.8961 mL24.4804 mL
10 mM0.2448 mL1.2240 mL2.4480 mL12.2402 mL
20 mM0.1224 mL0.6120 mL1.2240 mL6.1201 mL
DMSO
1mg5mg10mg50mg
50 mM0.0490 mL0.2448 mL0.4896 mL2.4480 mL
100 mM0.0245 mL0.1224 mL0.2448 mL1.2240 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

M3 mAChRM2 mAChRM1 mAChRHistamineReceptorHistamine ReceptorH1 receptorDimethindene Maleate(S)(+)Dimethindene maleate(S) (+) Dimethindene maleate
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